Synthetic lethal interactions, where mutation of one gene renders cells sensitive to inhibition
of another gene, can be exploited for the development of targeted therapeutics in cancer …

Proper subcellular localization is crucial for the functioning of biomacromolecules, including
proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the …

Transcription factors (TFs) are frequently mutated in cancer. Paediatric cancers exhibit few
mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which …

Cancer dependency maps have accelerated the discovery of tumor vulnerabilities that can
be exploited as drug targets when translatable to patients. The Cancer Genome Atlas …

Synthetic lethality is a genetic interaction that results in cell death when two genetic
deficiencies co-occur but not when either deficiency occurs alone, which can be co-opted for …

Conditional degron tags (CDTs) are a powerful tool for target validation that combines the
kinetics and reversible action of pharmacological agents with the generalizability of genetic …

In the past two decades, technological advances have brought unprecedented insights into
the paediatric cancer genome revealing characteristics distinct from those of adult cancer …

Tumor cells can result from gene mutations and over-expression. Synthetic lethality (SL)
offers a desirable setting where cancer cells bearing one mutated gene of an SL gene pair …

Pediatric cancers are frequently driven by genomic alterations that result in aberrant
transcription factor activity. Here, we used functional genomic screens to identify multiple …

Transcriptional co-regulators have been widely pursued as targets for disrupting oncogenic
gene regulatory programs. However, many proteins in this target class are universally …