Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options

J Jankowski, J Floege, D Fliser, M Böhm, N Marx - Circulation, 2021 - Am Heart Assoc
Patients with chronic kidney disease (CKD) exhibit an elevated cardiovascular risk
manifesting as coronary artery disease, heart failure, arrhythmias, and sudden cardiac …

Medial Arterial Calcification: JACC State-of-the-Art Review

P Lanzer, FM Hannan, JD Lanzer, J Janzen… - Journal of the American …, 2021 - jacc.org
Medial arterial calcification (MAC) is a chronic systemic vascular disorder distinct from
atherosclerosis that is frequently but not always associated with diabetes mellitus, chronic …

Targeting vascular calcification in chronic kidney disease

AJ Nelson, P Raggi, M Wolf, AM Gold… - Basic to Translational …, 2020 - jacc.org
Cardiovascular (CV) disease remains an important cause of morbidity and mortality for
patients with chronic kidney disease (CKD). Although clustering of traditional risk factors with …

Cardiovascular calcification heterogeneity in chronic kidney disease

JD Hutcheson, C Goettsch - Circulation Research, 2023 - Am Heart Assoc
Patients with chronic kidney disease (CKD) exhibit tremendously elevated risk for
cardiovascular disease, particularly ischemic heart disease, due to premature vascular and …

Multicenter randomized controlled trial of vitamin K antagonist replacement by rivaroxaban with or without vitamin K2 in hemodialysis patients with atrial fibrillation: the …

AS De Vriese, R Caluwé, L Pyfferoen… - Journal of the …, 2020 - journals.lww.com
Background Vitamin K antagonists (VKAs), although commonly used to reduce
thromboembolic risk in atrial fibrillation, have been incriminated as probable cause of …

Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo

G Wang, Y Wang, Q Yang, C Xu, Y Zheng… - Cell Death & …, 2022 - nature.com
Methylglyoxal (MGO) is an active metabolite of glucose and plays a prominent role in the
pathogenesis of diabetic vascular complications, including endothelial cell apoptosis …

Uraemic solutes as therapeutic targets in CKD-associated cardiovascular disease

JD Ravid, MH Kamel, VC Chitalia - Nature Reviews Nephrology, 2021 - nature.com
Chronic kidney disease (CKD) is characterized by the retention of a myriad of solutes termed
uraemic (or uremic) toxins, which inflict damage to several organs, including the …

Interventions to attenuate vascular calcification progression in chronic kidney disease: a systematic review of clinical trials

C Xu, ER Smith, MK Tiong, I Ruderman… - Journal of the …, 2022 - journals.lww.com
Interventions To Attenuate Vascular Calcification Progressio... : Journal of the American
Society of Nephrology Interventions To Attenuate Vascular Calcification Progression in Chronic …

[HTML][HTML] Strategies for phosphate control in patients with CKD

FC Barreto, DV Barreto, ZA Massy… - Kidney international reports, 2019 - Elsevier
Hyperphosphatemia is a common complication in patients with chronic kidney disease
(CKD), particularly in those requiring renal replacement therapy. The importance of …

[HTML][HTML] Hyperphosphatemia and cardiovascular disease

C Zhou, Z Shi, N Ouyang, X Ruan - Frontiers in Cell and …, 2021 - frontiersin.org
Hyperphosphatemia or even serum phosphate levels within the “normal laboratory range”
are highly associated with increased cardiovascular disease risk and mortality in the general …