Okadaic acid meet and greet: An insight into detection methods, response strategies and genotoxic effects in marine invertebrates

MV Prego-Faraldo, V Valdiglesias, J Méndez… - Marine Drugs, 2013 - mdpi.com
Harmful Algal Blooms (HABs) constitute one of the most important sources of contamination
in the oceans, producing high concentrations of potentially harmful biotoxins that are …

[HTML][HTML] Induction to oxidative stress by saxitoxin investigated through lipid peroxidation in Neuro 2A cells and Chlamydomonas reinhardtii alga

SP Melegari, F Perreault, S Moukha, R Popovic… - Chemosphere, 2012 - Elsevier
Saxitoxin (STX) is a cyanotoxin, which can cause neurotoxic effects and induce ecological
changes in aquatic environments, a potential risk to public and environmental health. Many …

Impacts of the toxic benthic dinoflagellate Prorocentrum lima on the brown mussel Perna perna: Shell-valve closure response, immunology, and histopathology

RAF Neves, TC Santiago, WF Carvalho… - Marine environmental …, 2019 - Elsevier
Prorocentrum lima is a widely distributed marine benthic dinoflagellate that produces
diarrhetic toxins, okadaic acid (OA) and its analogs, that may promote damage on bivalve …

Effect of okadaic acid on carpet shell clam (Ruditapes decussatus) haemocytes by in vitro exposure and harmful algal bloom simulation assays

M Prado-Alvarez, F Flórez-Barrós, J Méndez… - Cell Biology and …, 2013 - Springer
Okadaic acid (OA), produced by dinoflagellates during harmful algal blooms (HAB), belongs
to the Diarrheic Shellfish Poisoning toxins that cause gastrointestinal symptoms in humans …

Ingenuity network-assisted transcription profiling: Identification of a new pharmacologic mechanism for MK886

AL Mayburd, A Martlinez, D Sackett, H Liu, J Shih… - Clinical cancer …, 2006 - AACR
The small molecular inhibitor MK886 is known to block 5-lipoxygenase-activating protein
ALOX5AP and shows antitumor activity in multiple human cell lines. The broad antitumor …

Transcriptional and biochemical analysis of antioxidant enzymes in the mussel Mytilus galloprovincialis during experimental exposures to the toxic dinoflagellate …

MV Prego-Faraldo, LR Vieira, JM Eirin-Lopez… - Marine environmental …, 2017 - Elsevier
The genotoxic and cytotoxic effects of Diarrhetic Shellfish Poisoning (DSP) toxins have been
widely investigated in bivalve molluscs, representing the main vectors of these compounds …

Impact of harmful algal blooms (Dinophysis acuminata) on the immune system of oysters and mussels from Santa Catarina, Brazil

E Simões, RC Vieira, MA Schramm… - Journal of the Marine …, 2015 - cambridge.org
Blooms of the harmful alga Dinophysis acuminata, which produces okadaic acid (OA), are
becoming recurrent in Santa Catarina coast, where most of the shellfish marine farms in …

Proteomic profile in Perna viridis after exposed to Prorocentrum lima, a dinoflagellate producing DSP toxins

L Huang, Y Zou, H Weng, HY Li, JS Liu… - Environmental Pollution, 2015 - Elsevier
In the current study, we compared protein profiles in gills of Perna viridis after exposure to
Prorocentrum lima, a dinoflagellate producing DSP toxins, and identified the differential …

Genetic and genotoxic impacts in the oyster Crassostrea gigas exposed to the harmful alga Alexandrium minutum

AM Mat, H Haberkorn, JP Bourdineaud… - Aquatic Toxicology, 2013 - Elsevier
Genotoxic, genetic and behavioral impacts of the paralytic shellfish toxin (PST)-producing
alga Alexandrium minutum on the oyster Crassostrea gigas were assessed using RAPD …

Evaluation of DNA damage induced by decabromodiphenyl ether (BDE‐209) in hemocytes of Dreissena polymorpha using the comet and micronucleus assays

C Riva, A Binelli, D Cogni… - Environmental and …, 2007 - Wiley Online Library
The recent widespread production and use of flame retardants, polybrominated diphenyl
ethers (PBDEs), is one of the reason of the increasing contamination observed worldwide. At …