Emerging molecular markers towards potential diagnostic panels for lupus
G Tan, B Baby, Y Zhou, T Wu - Frontiers in Immunology, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease which can affect
various tissues and organs, posing significant challenges for clinical diagnosis and …
various tissues and organs, posing significant challenges for clinical diagnosis and …
Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus
R Lande, R Palazzo, N Gestermann, C Jandus… - Scientific reports, 2020 - nature.com
LL37 exerts a dual pathogenic role in psoriasis. Bound to self-DNA/RNA, LL37 licenses
autoreactivity by stimulating plasmacytoid dendritic cells-(pDCs)-Type I interferon (IFN-I) and …
autoreactivity by stimulating plasmacytoid dendritic cells-(pDCs)-Type I interferon (IFN-I) and …
Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype
A Stachowicz, R Pandey, N Sundararaman… - Journal of …, 2022 - Springer
Background Macrophages are effector cells of the innate immune system that undergo
phenotypical changes in response to organ injury and repair. These cells are most often …
phenotypical changes in response to organ injury and repair. These cells are most often …
Complementary effects of carbamylated and citrullinated LL37 in autoimmunity and inflammation in systemic lupus erythematosus
R Lande, I Pietraforte, A Mennella, R Palazzo… - International Journal of …, 2021 - mdpi.com
LL37 acts as T-cell/B-cell autoantigen in Systemic lupus erythematosus (SLE) and psoriatic
disease. Moreover, when bound to “self” nucleic acids, LL37 acts as “danger signal,” leading …
disease. Moreover, when bound to “self” nucleic acids, LL37 acts as “danger signal,” leading …
Study of Plasma Anti-CD26 Autoantibody Levels in a Cohort of Treatment-Naïve Early Arthritis Patients
OJ Cordero, I Viéitez, I Altabás, L Nuño-Nuño… - Archivum Immunologiae …, 2022 - Springer
In rheumatoid arthritis (RA), the identification of biomarkers to adjust treatment intensity and
to correctly diagnose the disease in early stages still constitutes a challenge and, as such …
to correctly diagnose the disease in early stages still constitutes a challenge and, as such …
Study of plasma anti-CD26 autoantibody levels in a cohort of treatment-naïve early arthritis patients
ÓJ Cordero Santamaría, I Viéitez González… - 2022 - minerva.usc.es
In rheumatoid arthritis (RA), the identifcation of biomarkers to adjust treatment intensity and
to correctly diagnose the disease in early stages still constitutes a challenge and, as such …
to correctly diagnose the disease in early stages still constitutes a challenge and, as such …
Role of Irreversible Post-Translational Modifications of Autoantigens in Systemic Lupus Erythematosus: LL37 as a Model Autoantigen
Abstract Systemic Lupus Erythematosus (SLE) is a devastating disease, which affects
several organs and with poor therapeutic options. Cathelicin LL37 is an antimicrobial …
several organs and with poor therapeutic options. Cathelicin LL37 is an antimicrobial …