Best practices for single-cell analysis across modalities
Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
The emerging landscape of spatial profiling technologies
Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …
profiling methods as a major pillar for cellular atlas building of complex samples, from …
The expanding vistas of spatial transcriptomics
The formation and maintenance of tissue integrity requires complex, coordinated activities
by thousands of genes and their encoded products. Until recently, transcript levels could …
by thousands of genes and their encoded products. Until recently, transcript levels could …
Spatial components of molecular tissue biology
Methods for profiling RNA and protein expression in a spatially resolved manner are rapidly
evolving, making it possible to comprehensively characterize cells and tissues in health and …
evolving, making it possible to comprehensively characterize cells and tissues in health and …
Spatial biology of cancer evolution
Z Seferbekova, A Lomakin, LR Yates… - Nature Reviews …, 2023 - nature.com
The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …
driving forces of cancer development are mutation and selection of fitter clones. Cancer …
Squidpy: a scalable framework for spatial omics analysis
Spatial omics data are advancing the study of tissue organization and cellular
communication at an unprecedented scale. Flexible tools are required to store, integrate and …
communication at an unprecedented scale. Flexible tools are required to store, integrate and …
Deciphering spatial domains from spatially resolved transcriptomics with an adaptive graph attention auto-encoder
Recent advances in spatially resolved transcriptomics have enabled comprehensive
measurements of gene expression patterns while retaining the spatial context of the tissue …
measurements of gene expression patterns while retaining the spatial context of the tissue …
A comprehensive benchmarking with practical guidelines for cellular deconvolution of spatial transcriptomics
Spatial transcriptomics technologies are used to profile transcriptomes while preserving
spatial information, which enables high-resolution characterization of transcriptional patterns …
spatial information, which enables high-resolution characterization of transcriptional patterns …
The dawn of spatial omics
Spatial omics has been widely heralded as the new frontier in life sciences. This term
encompasses a wide range of techniques that promise to transform many areas of biology …
encompasses a wide range of techniques that promise to transform many areas of biology …
Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH
Methods to spatially profile the transcriptome are dominated by a trade-off between
resolution and throughput. Here we develop a method named Enhanced ELectric …
resolution and throughput. Here we develop a method named Enhanced ELectric …