Neutrophils play a critical role in the host defense against bacterial and fungal infections, but
their inappropriate activation also contributes to tissue damage during autoimmune and …

Phagocytosis, the regulated uptake of large particles (> 0.5 μm in diameter), is essential for
tissue homeostasis and is also an early, critical component of the innate immune response …

Cell-mediated drug-delivery systems have received considerable attention for their
enhanced therapeutic specificity and efficacy in cancer treatment. Neutrophils (NEs), the …

Immunosenescence is the functional deterioration of the immune system during natural
aging. Despite increased susceptibility to bacterial infections in older adults, age-associated …

Neutrophil recruitment to inflammation sites purportedly depends on sequential waves of
chemoattractants. Current models propose that leukotriene B 4 (LTB 4), a secondary …

Bloodstream infection is a hallmark of sepsis, a medically emergent condition requiring rapid
treatment. However, up-regulation of host defense proteins through Toll-like receptors …

Wound healing is a complex process that is characterized by an initial inflammatory phase
followed by a proliferative phase. This transition is a critical regulatory point; however, the …

A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here
we summarize recent findings on the initial steps in chemokine receptor–induced signal …

Though chronic autoimmune disorders such as rheumatoid arthritis or systemic lupus
erythematosus affect a significant percentage of the human population and strongly diminish …

Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate
and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into …