Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

CW Shields Iv, CD Reyes, GP López - Lab on a Chip, 2015 - pubs.rsc.org
Accurate and high throughput cell sorting is a critical enabling technology in molecular and
cellular biology, biotechnology, and medicine. While conventional methods can provide high …

Inertial microfluidic physics

H Amini, W Lee, D Di Carlo - Lab on a Chip, 2014 - pubs.rsc.org
Microfluidics has experienced massive growth in the past two decades, and especially with
advances in rapid prototyping researchers have explored a multitude of channel structures …

Particle separation and sorting in microfluidic devices: a review

P Sajeesh, AK Sen - Microfluidics and nanofluidics, 2014 - Springer
Separation and sorting of micron-sized particles has great importance in diagnostics,
chemical and biological analyses, food and chemical processing and environmental …

Inertial focusing in microfluidics

JM Martel, M Toner - Annual review of biomedical engineering, 2014 - annualreviews.org
When Segré and Silberberg in 1961 witnessed particles in a laminar pipe flow congregating
at an annulus in the pipe, scientists were perplexed and spent decades learning why such …

Isolation and retrieval of circulating tumor cells using centrifugal forces

HW Hou, ME Warkiani, BL Khoo, ZR Li, RA Soo… - Scientific reports, 2013 - nature.com
Presence and frequency of rare circulating tumor cells (CTCs) in bloodstreams of cancer
patients are pivotal to early cancer detection and treatment monitoring. Here, we use a spiral …

Inertial microfluidics

D Di Carlo - Lab on a Chip, 2009 - pubs.rsc.org
Despite the common wisdom that inertia does not contribute to microfluidic phenomena,
recent work has shown a variety of useful effects that depend on fluid inertia for applications …

Nonlinear microfluidics

D Stoecklein, D Di Carlo - Analytical chemistry, 2018 - ACS Publications
Microfluidic flow is commonly employed in the biological, chemical, or physical analysis of
samples in small fluid volumes because of the typical lack of nonlinear phenomena, with …

Continuous separation of cells and particles in microfluidic systems

A Lenshof, T Laurell - Chemical Society Reviews, 2010 - pubs.rsc.org
The progress in microfabrication and lab-on-a-chip technologies has been a major area of
development for new approaches to bioanalytics and integrated concepts for cell biology …

Spiral microchannel with rectangular and trapezoidal cross-sections for size based particle separation

G Guan, L Wu, AA Bhagat, Z Li, PCY Chen, S Chao… - Scientific reports, 2013 - nature.com
The paper reports a new method for three-dimensional observation of the location of
focused particle streams along both the depth and width of the channel cross-section in …

High-yield cell ordering and deterministic cell-in-droplet encapsulation using Dean flow in a curved microchannel

EWM Kemna, RM Schoeman, F Wolbers, I Vermes… - Lab on a Chip, 2012 - pubs.rsc.org
In this article high-yield (77%) and high-speed (2700 cells s− 1) single cell droplet
encapsulation is described using a Dean-coupled inertial ordering of cells in a simple …