Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …

Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of
those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with …

The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance
of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease …

Endosomal protein sorting controls the localization of many physiologically important
proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the …

Mitochondrial dysfunction represents a critical step during the pathogenesis of Parkinson's
disease (PD), and increasing evidence suggests abnormal mitochondrial dynamics and …

To mediate the degradation of biomacromolecules, lysosomes must traffic towards cargo-
carrying vesicles for subsequent membrane fusion or fission. Mutations of the lysosomal …

Emerging findings disclose unexpected components of G protein-coupled receptor (GPCR)
signaling and cell biology. Select GPCRs exhibit classical signaling, that is restricted to cell …

Parkinson disease (PD) and Parkinson-plus syndromes are genetically heterogeneous
neurological diseases. Initial studies into the genetic causes of PD relied on classical …

Vacuolar protein sorting-35 (VPS35) is essential for endosome-to-Golgi retrieval of
membrane proteins. Mutations in the VPS35 gene have been identified in patients with …

ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as
nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives …