Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) or prion
disease of sheep and goats. Scrapie is a protein misfolding disease where the normal prion …

Prion diseases are a group of inevitably fatal neurodegenerative disorders affecting
numerous mammalian species, including humans. The existence of heritable phenotypes of …

Bank voles are uniquely susceptible to a wide range of prion strains isolated from many
different species. To determine if this enhanced susceptibility to interspecies prion …

Prion diseases are fatal neurodegenerative diseases of humans and animals characterized
by gray matter spongiosis and accumulation of aggregated, misfolded, protease-resistant …

In order to assess the susceptibility of bank voles to chronic wasting disease (CWD), we
inoculated voles carrying isoleucine or methionine at codon 109 (Bv109I and Bv109M …

Abstract Gerstmann-Sträussler-Scheinker disease (GSS) is an inherited neurodegenerative
disorder associated with mutations in the prion protein gene and accumulation of misfolded …

Chronic wasting disease (CWD) is a fatal prion disease of North American deer and elk and
poses an unclear risk for transmission to humans. Human exposure to CWD occurs through …

The protein-only hypothesis predicts that infectious mammalian prions are composed solely
of PrPSc, a misfolded conformer of the normal prion protein, PrPC. However, protein-only …

Prion diseases are caused by the misfolding of a host-encoded glycoprotein, PrPC, into a
pathogenic conformer, PrPSc. Infectious prions can exist as different strains, composed of …

Chronic wasting disease (CWD) is a highly contagious always fatal neurodegenerative
disease that is currently known to naturally infect only species of the deer family, Cervidae …