Mitochondrial architecture is involved in several functions crucial for cell viability,
proliferation, senescence, and signaling. In particular, mitochondrial dynamics, through the …

A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

The ancestors of marine mammals once roamed the land and independently committed to
an aquatic lifestyle. These macroevolutionary transitions have intrigued scientists for …

Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural
feature, providing the physical basis for intercommunication during Ca2+ signalling; yet, the …

Mitofusin 2 (Mfn2) is a key protein in mitochondrial fusion and it participates in the bridging
of mitochondria to the endoplasmic reticulum (ER). Recent data indicate that Mfn2 ablation …

One of the novel interesting topics in the study of cardiovascular disease is the role of the
oxidation system, since inflammation and oxidative stress are known to lead to …

In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting
network. The molecular machinery that mediates this organelle fission and fusion is …

Mitochondria are key decoding stations of the apoptotic process. In support of this view, a
large body of experimental evidence has unambiguously revealed that, in addition to the …

The endoplasmic reticulum (ER) and mitochondria are physically connected to form
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …

Mitochondria are no longer considered to be solely the static powerhouses of the cell. While
they are undoubtedly essential to sustaining life and meeting the energy requirements of the …