Clefts of the lip and/or palate (CLP) are common birth defects of complex aetiology. CLP can
occur in isolation or as part of a broad range of chromosomal, Mendelian or teratogenic …

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …

The events that convert adherent epithelial cells into individual migratory cells that can
invade the extracellular matrix are known collectively as epithelial-mesenchymal transition …

Neural crest cells (NCC) are a transient, embryonic cell population characterized by unusual
migratory ability and developmental plasticity. To annotate and characterize cis-regulatory …

Major differences in facial morphology distinguish vertebrate species. Variation of facial
traits underlies the uniqueness of human individuals, and abnormal craniofacial …

With an average worldwide prevalence of approximately 1.2/1000 live births, orofacial clefts
are the most common craniofacial birth defects in humans. Like other complex disorders …

Previously we have shown that nonsyndromic cleft lip with or without cleft palate (NSCL/P) is
strongly associated with SNPs in IRF6 (interferon regulatory factor 6). Here, we use …

Clefts of the lip and palate (CLP), the major causes of congenital facial malformation
globally, result from failure of fusion of the facial processes during embryogenesis. With a …

Orofacial clefts are the most common craniofacial birth defects and one of the most common
congenital malformations in humans. They require complex multidisciplinary treatment and …

Cell fate commitment involves the progressive restriction of developmental potential. Recent
studies have shown that this process requires not only shifts in gene expression but also an …