It has been almost two decades since the first link between microRNAs and cancer was
established. In the ensuing years, this abundant class of short noncoding regulatory RNAs …

Since the discovery of the first microRNAs (miRNAs, miRs), the understanding of miRNA
biology has expanded substantially. miRNAs are involved and described as master …

Internal tandem duplication (ITD) mutations within FMS-like tyrosine kinase-3 (FLT3) occur
in up to 30% of acute myeloid leukemia (AML) patients and confer a very poor prognosis …

Small non-coding microRNAs (miRNAs) are instrumental in physiological processes, such
as proliferation, cell cycle, apoptosis, and differentiation, processes which are often …

Acute myeloid leukemia (AML) is a deadly hematologic malignancy characterized by the
uncontrolled growth of immature myeloid cells. Over the past several decades, we have …

Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Abstract MicroRNAs (miRNAs), small non-coding RNAs that repress target genes, are a
promising new focus of targeted therapeutics for cancer. miR-155 is a well-studied miRNA …

Oxidative stress (OS), characterized by the excessive accumulation of reactive oxygen
species (ROS), is an emerging hallmark of cancer. Tumorigenesis and development driven …

We discovered that the survival and growth of many primary acute myeloid leukemia (AML)
samples and cell lines, but not normal CD34+ cells, are dependent on SIRT5, a lysine …

Tumor associated macrophage responses are regulated by distinct metabolic states that
affect their function. However, the ability of specific signals in the local tumor …