RNA polymerase II (Pol II) transcribes hundreds of thousands of transcription units–a
reaction always brought to a close by its termination. Because Pol II transcribes multiple …

Therapeutic oligonucleotides interact with a target RNA via Watson-Crick complementarity,
affecting RNA-processing reactions such as mRNA degradation, pre-mRNA splicing, or …

The 3′-end processing machinery for metazoan replication-dependent histone precursor
messenger RNAs (pre-mRNAs) contains the U7 small nuclear ribonucleoprotein and shares …

Histone locus bodies (HLBs) are biomolecular condensates that assemble at replication-
dependent (RD) histone genes in animal cells. These genes produce unique mRNAs that …

Metazoan replication-dependent histone pre-mRNAs are cleaved at the 3′ end by U7
snRNP, an RNA-guided endonuclease that contains U7 snRNA, seven proteins of the Sm …

In animal cells, replication-dependent histone mRNAs end with a highly conserved stem–
loop structure followed by a 4-to 5-nucleotide single-stranded tail. This unique 3′ end …

CPSF73 is the endonuclease that catalyzes the cleavage reaction for 3′-end processing of
mRNA precursors (pre-mRNAs) in two distinct machineries, a canonical machinery for the …

Human pre-mRNA processing relies on multi-subunit macromolecular complexes, which
recognize specific RNA sequence elements essential for assembly and activity. Canonical …

Lung adenocarcinoma (LUAD) is one of the deadliest cancers regarding both mortality rate
and number of deaths and warrants greater effort in the development of potential therapeutic …

U7 snRNA is a 60-nucleotide component of U7 snRNP, a multi-subunit endonuclease that
cleaves precursors of metazoan replication-dependent histone mRNAs at the 3-prime end …