The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

The conversion of acetylcholine binding into ion conduction across the membrane is
becoming more clearly understood in terms of the structure of the receptor and its transitions …

New textbooks at all levels of chemistry appear with great regularity. Some fields like basic
biochemistry, organic reaction mechanisms, and chemical thermody namics are well …

The nicotinic acetylcholine receptor controls electrical signalling between nerve and muscle
cells by opening and closing a gated, membrane-spanning pore. Here we present an atomic …

Instituí de Biologie Physico-Chimique and College de France, 13 rue Pierre et Marie Curie,
F-75005 Paris, France, and Department of Molecular Biophysicsand Biochemistry, Yale …

Binding, gating, a nity and e cacy Page 1 SEMINAR Binding, gating, a nity and e cacy The nature
of the problem Some history The classical era The interaction between binding and conformation …

The neurotransmitter serotonin (5HT) activates a variety of second messenger signaling
systems and through them indirectly regulates the function of ion channels. Serotonin also …

nAChRs are pentameric transmembrane proteins into the superfamily of ligand-gated ion
channels that includes the 5HT3, glycine, GABAA, and GABAC receptors. Electron …

Amino-acid sequences derived from complementary DMAs encoding the α-and β-subunits
of the GAB A/benzo diazepine receptor from bovine brain show homology with other ligand …

Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …