The way in which cells coordinate their behaviours during various biological processes,
including morphogenesis, cancer progression and tissue remodelling, largely depends on …

From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

A fundamental feature of multicellular organisms is their ability to self-repair wounds through
the movement of epithelial cells into the damaged area. This collective cellular movement is …

The collective behaviour of cells in epithelial tissues is dependent on their mechanical
properties. However, the contribution of tissue mechanics to wound healing in vivo remains …

Following skin wounding, the healing outcome can be: regeneration, repair with normal scar
tissue, repair with hypertrophic scar tissue or the formation of keloids. The role of chemical …

Drosophila melanogaster has been extensively used to study the humoral arm of innate
immunity because of the developmental and functional parallels with mammalian innate …

Background Reestablishing epithelial integrity and biosynthetic capacity is critically
important following tissue damage. The adult Drosophila abdominal epithelium provides an …

Planar in vitro models have been invaluable tools to identify the mechanical basis of wound
closure. Although these models may recapitulate closure dynamics of epithelial cell sheets …

The closure of gaps is crucial to maintaining epithelium integrity during developmental and
repair processes such as dorsal closure and wound healing. Depending on biochemical as …

The actomyosin cytoskeleton is responsible for most force-driven processes in cells and
tissues. How it assembles into the necessary structures at the right time and place is an …