Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected
insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory …

Centrioles are ancient organelles that build centrosomes, the major microtubule-organizing
centers of animal cells. Extra centrosomes are a common feature of cancer cells. To …

Spermatozoa contain highly specialized structural features reflecting unique functions
required for fertilization. Among them, the flagellum is a sperm-specific organelle required to …

Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the
presence of extra centrosomes,,,. However, a direct mechanistic link between extra …

Centrosomes are microtubule-organizing centres of animal cells. They influence the
morphology of the microtubule cytoskeleton, function as the base for the primary cilium and …

The centrosome is the main microtubule organization centre of animal cells. It is composed
of a centriole pair surrounded by pericentriolar material (PCM). Traditionally described as …