Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Skeletal muscle consists of bundles of myofibers containing millions of myofibrils, each of
which is formed of longitudinally aligned sarcomere structures. Sarcomeres are the …

Electron microscope studies have shown that the switched-off state of myosin II in muscle
involves intramolecular interaction between the two heads of myosin and between one head …

Striated muscle myosin is a multidomain ATP-dependent molecular motor. Alterations to
various domains affect the chemomechanical properties of the motor, and they are …

Correct specification of myofilament length is essential for efficient skeletal muscle
contraction. The length of thin actin filaments can be explained by a novel'two …

In striated muscle tropomyosin (Tm) extends along the length of F-actin-containing thin
filaments. Its location governs access of myosin binding sites on actin and, hence, force …

Animals require different types of muscle for survival, for example for circulation, motility,
reproduction and digestion. Much emphasis in the muscle field has been placed on …

Striated muscle is an elegant system for study at many levels. Much has been learned about
the mechanism of contraction from studying the mechanical properties of intact and …

During muscle development myosin molecules form symmetrical thick filaments, which
integrate with the thin filaments to produce the regular sarcomeric lattice. In Drosophila …

Dilated cardiomyopathy (DCM), a life-threatening disease characterized by pathological
heart enlargement, can be caused by myosin mutations that reduce contractile function. To …