Heart failure with preserved ejection fraction (HFpEF), a major public health problem that is
rising in prevalence, is associated with high morbidity and mortality and is considered to be …

The mammalian heart is responsible for not only pumping blood throughout the body but
also adjusting this pumping activity quickly depending upon sudden changes in the …

Single cardiomyocytes contain myofibrils that harbor the sarcomere-based contractile
machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem …

INTRODUCTION Along with its well-documented role as a track for cargo transport, the
microtubule (MT) cytoskeleton is linked to diverse structural and signaling roles in the …

Most natural (or biological) materials are complex composites whose mechanical properties
are often outstanding, considering the weak constituents from which they are assembled …

The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …

Pre-clinical diastolic dysfunction (PDD) has been broadly defined as left ventricular diastolic
dysfunction without the diagnosis of congestive heart failure (HF) and with normal systolic …

The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein
titin, which is a scaffolding filament, signaling platform, and provider of passive tension and …

Titin is a giant vertebrate striated muscle protein with critical importance for myofibril
elasticity and structural integrity. We show here that the complete sequence of the human …

Alternative splicing has a major role in cardiac adaptive responses, as exemplified by the
isoform switch of the sarcomeric protein titin, which adjusts ventricular filling. By positional …