Despite an ever-growing prevalence and increasing economic burden of Alzheimer's
disease (AD) and Parkinson's disease (PD), recent advances in drug development have …

Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia,
responsible for the onset of several long-term complications. Recent evidence suggests that …

A diagnosis of diabetes mellitus and prediabetes has been associated with increased risk of
Parkinson's disease (PD) in several studies, but results have not been entirely consistent …

Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most frequent
neurodegenerative disorders. Despite their pathophysiological and clinical differences, they …

Recent clinical guidelines have emphasized the importance of screening for cognitive
impairment in older adults with diabetes, however, there is still a lack of understanding about …

In numerous brain structures, insulin signaling modulates the homeostatic processes,
sensitivity to reward pathways, executive function, memory, and cognition. Through human …

In the last decade, attention has become greater to the relationship between
neurodegeneration and abnormal insulin signaling in the central nervous system, as insulin …

Impairments in systematic and regional glucose metabolism exist in patients with
Parkinson's disease (PD) at every stage of the disease course, and such impairments are …