The skin is comprised of different cell types with different proliferative capacities. Skin aging
occurs with chronological age and upon exposure to extrinsic factors such as photodamage …

Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …

Background: Success or failure of plastic surgery procedures relies on cosmetic results.
Understanding the objective perception of favorable aesthetic results is critical to ensure …

RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …

Ageing is a process that inevitably affects most living organisms and involves the
accumulation of macromolecular damage, genomic instability and loss of heterochromatin …

Most patients who undergo cosmetic rejuvenation treatment hope to appear younger and
healthier. Although a number of scales have been put forward to assess facial aging, to date …

Pathway choice within DNA double-strand break (DSB) repair is a tightly regulated process
to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome …

The RecQ helicase RECQL4, mutated in Rothmund-Thomson syndrome, regulates genome
stability, aging, and cancer. Here, we identify a crucial role for RECQL4 in DNA end …

Aging, the universal phenomenon, affects human health and is the primary risk factor for
major disease pathologies. Progeroid diseases, which mimic aging at an accelerated rate …

Cellular senescence is the final fate of most cells in response to specific stimuli, but is not the
end. Indeed, it is the beginning of a singular life, with multiple side roads leading to diverse …