Understanding the complex phage-host interactions in biofilm communities

DP Pires, LDR Melo, J Azeredo - Annual Review of Virology, 2021 - annualreviews.org
Bacteriophages and bacterial biofilms are widely present in natural environments, a fact that
has accelerated the evolution of phages and their bacterial hosts in these particular niches …

Biological foundations of successful bacteriophage therapy

C Venturini, A Petrovic Fabijan… - EMBO Molecular …, 2022 - embopress.org
Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

Phage Paride can kill dormant, antibiotic-tolerant cells of Pseudomonas aeruginosa by direct lytic replication

E Maffei, AK Woischnig, MR Burkolter, Y Heyer… - Nature …, 2024 - nature.com
Bacteriophages are ubiquitous viral predators that have primarily been studied using fast-
growing laboratory cultures of their bacterial hosts. However, microbial life in nature is …

Combination of genetically diverse Pseudomonas phages enhances the cocktail efficiency against bacteria

A Naknaen, T Samernate, W Wannasrichan… - Scientific Reports, 2023 - nature.com
Phage treatment has been used as an alternative to antibiotics since the early 1900s.
However, bacteria may acquire phage resistance quickly, limiting the use of phage …

Genome-driven elucidation of phage-host interplay and impact of phage resistance evolution on bacterial fitness

P Markwitz, C Lood, T Olszak, V van Noort… - The ISME …, 2022 - academic.oup.com
When considering the interactions between bacteriophages and their host, the issue of
phage-resistance emergence is a key element in understanding the ecological impact of …

[HTML][HTML] An overview of the current state of phage therapy for the treatment of biofilm-related infections

DP Pires, L Meneses, AC Brandao, J Azeredo - Current opinion in virology, 2022 - Elsevier
Bacterial biofilms are involved in many chronic and difficult-to-treat infections. Phage therapy
against infectious biofilms is becoming a promising strategy, as suggested by the increasing …

Unveil the secret of the bacteria and phage arms race

Y Wang, H Fan, Y Tong - International Journal of Molecular Sciences, 2023 - mdpi.com
Bacteria have developed different mechanisms to defend against phages, such as
preventing phages from being adsorbed on the surface of host bacteria; through the …

A novel method to create efficient phage cocktails via use of phage-resistant bacteria

C Li, T Shi, Y Sun, Y Zhang - Applied and environmental …, 2022 - Am Soc Microbiol
The rapid antiphage mutation of pathogens is a big challenge often encountered in the
application of phages in aquaculture, animal husbandry, and human disease prevention. A …

The potential of bacteriophages to control Xanthomonas campestris pv. campestris at different stages of disease development

D Holtappels, KJ Fortuna, L Moons… - Microbial …, 2022 - Wiley Online Library
Xanthomonas campestris pv. campestris (Xcc) is a vascular pathogen that invades the xylem
of Brassica crops. Current chemical and antibiotics‐based control measures for this …

A lipopolysaccharide‐dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance

SL Warring, LM Malone, J Jayaraman… - Environmental …, 2022 - Wiley Online Library
Bacterial pathogens are major causes of crop diseases, leading to significant production
losses. For instance, kiwifruit canker, caused by the phytopathogen Pseudomonas syringae …