Computational tools for cellular scale biophysics

DB Stein, MJ Shelley - Current Opinion in Cell Biology, 2024 - Elsevier
Mathematical models are indispensable for disentangling the interactions through which
biological components work together to generate the forces and flows that position, mix, and …

Cytoplasmic stirring by active carpets

B Chakrabarti, M Rachh, SY Shvartsman… - Proceedings of the …, 2024 - pnas.org
Large cells often rely on cytoplasmic flows for intracellular transport, maintaining
homeostasis, and positioning cellular components. Understanding the mechanisms of these …

Twist and turn: elastohydrodynamics of microscale active fibres

M Lisicki - The European Physical Journal Special Topics, 2024 - Springer
Cellular locomotion often involves the motion of thin, elastic filaments, such as cilia and
flagella, in viscous environments. The manuscript serves as a general introduction to the …

A simulation platform for slender, semiflexible, and inextensible fibers with Brownian hydrodynamics and steric repulsion

O Maxian, A Donev - Physics of Fluids, 2024 - pubs.aip.org
The last few years have witnessed an explosion of new numerical methods for filament
hydrodynamics. Aside from their ubiquity in biology, physics, and engineering, filaments …

Series solution and its extension for the nonlinear flow response of soft hair beds

BH Sun, B Pang, M Li - Physics of Fluids, 2024 - pubs.aip.org
In nature and engineering applications, flexible fiber beds covering biological surfaces can
play a role in reducing resistance. These fibers deform under the action of fluids, and this …

A first-principles geometric model for dynamics of motor-driven centrosomal asters

YN Young, VG Herrera, HZ Huan, R Farhadifar… - bioRxiv, 2024 - biorxiv.org
The centrosomal aster is a mobile and adaptable cellular organelle that exerts and transmits
forces necessary for tasks such as nuclear migration and spindle positioning. Recent …

Flows, self-organization, and transport in living cells

MJ Shelley - Physical Review Fluids, 2024 - APS
This paper briefly reprises, with added commentary, a talk I gave on transport and flows
within living cells at an APS-DFD meeting. Directed transport is especially important in large …

Geometric model for dynamics of motor-driven centrosomal asters

YN Young, VG Herrera, H Zhang, R Farhadifar… - Physical Review …, 2025 - APS
The centrosomal aster is a mobile and adaptable cellular organelle that exerts and transmits
forces necessary for tasks such as nuclear migration and spindle positioning. Recent …

Mechanics of spindle orientation in human mitotic cells is determined by pulling forces on astral microtubules and clustering of cortical dynein

MI Anjur-Dietrich, VG Hererra, R Farhadifar, H Wu… - Developmental Cell, 2024 - cell.com
The forces that orient the spindle in human cells remain poorly understood due to a lack of
direct mechanical measurements in mammalian systems. We use magnetic tweezers to …