Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …

Autoimmune diseases are a family of chronic systemic inflammatory disorders, characterized
by the dysregulation of the immune system which finally results in the break of tolerance to …

During induction of trained immunity, monocytes and macrophages undergo a functional
and transcriptional reprogramming toward increased activation. Important rewiring of cellular …

Innate immune sensors that detect nucleic acids are attractive targets for therapeutic
intervention because of their diverse roles in many disease processes. In detecting RNA and …

Autoinflammatory diseases are defined as the loss of self-tolerance in which an
inflammatory response to self-antigens occurs, which are a significant global burden. Toll …

The metabolic shift that cancer cells undergo towards aerobic glycolysis was identified as a
defining feature in tumours almost 100 years ago; however, it has only recently become …

Isoliquiritigenin (ILG) is a flavonoid derived from Glycyrrhiza uralensis and potently
suppresses NLRP3 inflammasome activation resulting in the improvement of diet-induced …

Background Systemic sclerosis (SSc) is an autoimmune connective tissue disease
characterised by skin and internal organs fibrosis due to accumulation of extra cellular …