Molecular recognition in water using macrocyclic synthetic receptors constitutes a vibrant
and timely research area of supramolecular chemistry. Pioneering examples on the topic …

Conspectus Proteins exhibit high-binding affinity and selectivity, as well as remarkable
catalytic performance. Their binding pockets are hydrophobic but also contain polar and …

Molecular recognition in water involves contributions due to polar functional group
interactions, partial desolvation of polar and non-polar surfaces and changes in …

The incorporation of aryl substituents at the meso-positions of calix [4] pyrrole (C4P)
scaffolds produces aryl-extended (AE) and super-aryl-extended (SAE) calix [4] pyrroles. The …

We describe the synthesis of four water-soluble aryl-extended calix [4] pyrrole receptors and
report their binding properties with multiple neutral polar guests in water. The prepared …

We describe the synthesis of a tetrapyridinium phenyl extended calix [4] pyrrole that is
soluble in neutral water solution at mM concentrations. We show that, in pure water, the …

We describe the syntheses of the tetra-α isomers of three unprecedented super aryl-
extended calix [4] pyrroles (SAE-C [4] Ps) functionalized with either eight carboxylic acids …

Since the discovery that calix [4] pyrrole can act as a ligand for anions and other species that
can form multiple hydrogen bonds with its pyrrole NH units, this macrocyclic system, its …

Conformationally well-defined supramolecular complexes that can be studied in different
solvents provide a platform for separating and quantifying free energy contributions due to …

We describe the synthesis of two tetra-α aryl-extended calix [4] pyrroles (C [4] Ps) 4a–b
bearing four terminal carboxylic groups in their meso-propyl chains defining the lower rims …