Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2014–2016)

MC Breadmore, A Wuethrich, F Li, SC Phung… - …, 2017 - Wiley Online Library
One of the most cited limitations of capillary (and microchip) electrophoresis is the poor
sensitivity. This review continues to update this series of biennial reviews, first published in …

Sample preconcentration from dilute solutions on micro/nanofluidic platforms: A review

LM Fu, HH Hou, PH Chiu, RJ Yang - Electrophoresis, 2018 - Wiley Online Library
Biochemical detection plays a critical role in many analytical fields. For example, blood
samples include many proteins with relevance to disease diagnosis and therapeutic …

Recent advancements in ion concentration polarization

M Li, RK Anand - Analyst, 2016 - pubs.rsc.org
In this minireview, we discuss advancements in ion concentration polarization (ICP)-based
preconcentration, separation, desalination, and dielectrophoresis that have been made over …

dCas9-mediated nanoelectrokinetic direct detection of target gene for liquid biopsy

H Lee, J Choi, E Jeong, S Baek, HC Kim, JH Chae… - Nano …, 2018 - ACS Publications
The-state-of-the-art bio-and nanotechnology have opened up an avenue to noninvasive
liquid biopsy for identifying diseases from biomolecules in bloodstream, especially DNA. In …

Electrochemical detection of methylated DNA on a microfluidic chip with nanoelectrokinetic pre-concentration

SA Hong, YJ Kim, SJ Kim, S Yang - Biosensors and Bioelectronics, 2018 - Elsevier
DNA methylation is considered to be a promising marker for the early diagnosis and
prognosis of cancer. However, direct detection of the methylated DNAs in clinically relevant …

Enhancing the sensitivity of portable biosensors based on self-powered ion concentration polarization and electrical kinetic trapping

YJ Fan, MZ Huang, YC Hsiao, YW Huang, CZ Deng… - Nano Energy, 2020 - Elsevier
Preconcentration of biomolecules for detection on microfluidic platforms based on electrical
kinetic trapping (EKT) through ion concentration polarization (ICP) has been well developed …

Focusing, sorting, and separating microplastics by serial faradaic ion concentration polarization

CD Davies, RM Crooks - Chemical Science, 2020 - pubs.rsc.org
In this article, we report continuous sorting of two microplastics in a trifurcated microfluidic
channel using a new method called serial faradaic ion concentration polarization (fICP). fICP …

Recent advances in microscale extraction driven by ion concentration polarization

A Krishnamurthy, RK Anand - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Microscale extraction offers several distinct advantages over bench-scale processes
including increases in sample throughput, specificity, and efficiency. These attributes can be …

Tutorial review: Enrichment and separation of neutral and charged species by ion concentration polarization focusing

B Berzina, RK Anand - Analytica Chimica Acta, 2020 - Elsevier
Ion concentration polarization focusing (ICPF) is an electrokinetic technique, in which
analytes are enriched and separated along a localized electric field gradient in the presence …

Engineered nanofluidic preconcentration devices by ion concentration polarization

SY Son, S Lee, H Lee, SJ Kim - BioChip Journal, 2016 - Springer
A nanofluidic preconcentration device utilizing an ion concentration polarization (ICP)
phenomenon has been regarded as one of the most efficient mechanism for …