Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic
modulator and also as a neuromodulator at the synaptic level. We will present evidence to …

Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …

Adenosine is a ubiquitous homeostatic substance released from most cells, including
neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …

1 A degree of ambiguity and uncertainty exists concerning the distribution of mRNAs
encoding the four cloned adenosine receptors. In order to consolidate and extend current …

Adenosine receptor subtypes, first described 40 years ago, are known to regulate diverse
biological functions and have a role in various conditions, such as cerebral and cardiac …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

The A2A adenosine receptor (A2A‐AR) transcript and radioligand binding sites have a
distinct distribution in rat brain, restricted primarily to the striatum, nucleus accumbens and …

Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …

The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …