The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs
H Kuhn, L Humeniuk, N Kozlov, S Roigas, S Adel… - Progress in lipid …, 2018 - Elsevier
The reaction specificity of lipoxygenases (ALOX) impacts the biological activity of these
enzymes and also constitutes the decisive parameter for enzyme classification. ALOX15 …
enzymes and also constitutes the decisive parameter for enzyme classification. ALOX15 …
Molecular actors of inflammation and their signaling pathways: mechanistic insights from zebrafish
Simple Summary Inflammation is a central part of the body's response to harm that can be
elicited by microbes, environmental factors, or internal injuries. This complex physiological …
elicited by microbes, environmental factors, or internal injuries. This complex physiological …
PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo
CA Loynes, JA Lee, AL Robertson, MJG Steel… - Science …, 2018 - science.org
Neutrophils are the first immune cells recruited to a site of injury or infection, where they
perform many functions. Having completed their role, neutrophils must be removed from the …
perform many functions. Having completed their role, neutrophils must be removed from the …
Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish
A Katikaneni, M Jelcic, GF Gerlach, Y Ma… - Nature cell …, 2020 - nature.com
Rapid wound detection by distant leukocytes is essential for antimicrobial defence and post-
infection survival. The reactive oxygen species hydrogen peroxide and the polyunsaturated …
infection survival. The reactive oxygen species hydrogen peroxide and the polyunsaturated …
COVID-19. Pandemic surgery guidance
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …
protecting patients as well as healthcare staff and hereby provide this Guidance to address …
Macrophages undergo a behavioural switch during wound healing in zebrafish
T Sipka, SA Park, R Ozbilgic, L Balas, T Durand… - Free Radical Biology …, 2022 - Elsevier
In response to wound signals, macrophages are immediately recruited to the injury where
they acquire distinct phenotypes and functions, playing crucial roles both in host defense …
they acquire distinct phenotypes and functions, playing crucial roles both in host defense …
The fed-batch principle for the molecular biology lab: controlled nutrient diets in ready-made media improve production of recombinant proteins in Escherichia coli
M Krause, A Neubauer, P Neubauer - Microbial Cell Factories, 2016 - Springer
While the nutrient limited fed-batch technology is the standard of the cultivation of
microorganisms and production of heterologous proteins in industry, despite its advantages …
microorganisms and production of heterologous proteins in industry, despite its advantages …
The reaction specificity of mammalian ALOX15 orthologs is changed during late primate evolution and these alterations might offer evolutionary advantages for …
D Heydeck, F Reisch, M Schäfer… - Frontiers in cell and …, 2022 - frontiersin.org
Arachidonic acid lipoxygenases (ALOXs) have been implicated in the immune response of
mammals. The reaction specificity of these enzymes is decisive for their biological functions …
mammals. The reaction specificity of these enzymes is decisive for their biological functions …
Quantitative shotgun proteomics distinguishes wound-healing biomarker signatures in common carp skin mucus in response to Ichthyophthirius multifiliis
Ichthyophthirius multifiliis is a ciliated protozoan parasite recognized as one of the most
pathogenic diseases of wild and cultured freshwater fish. Fish skin mucus plays a significant …
pathogenic diseases of wild and cultured freshwater fish. Fish skin mucus plays a significant …
Structural considerations on lipoxygenase function, inhibition and crosstalk with nitric oxide pathways
I Wood, A Trostchansky, H Rubbo - Biochimie, 2020 - Elsevier
Lipoxygenases (LOX) are non-heme iron-containing enzymes that catalyze regio-and stereo-
selective dioxygenation of polyunsaturated fatty acids (PUFA). Mammalian LOXs participate …
selective dioxygenation of polyunsaturated fatty acids (PUFA). Mammalian LOXs participate …