The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs

H Kuhn, L Humeniuk, N Kozlov, S Roigas, S Adel… - Progress in lipid …, 2018 - Elsevier
The reaction specificity of lipoxygenases (ALOX) impacts the biological activity of these
enzymes and also constitutes the decisive parameter for enzyme classification. ALOX15 …

Molecular actors of inflammation and their signaling pathways: mechanistic insights from zebrafish

J Leiba, R Özbilgiç, L Hernández, M Demou, G Lutfalla… - Biology, 2023 - mdpi.com
Simple Summary Inflammation is a central part of the body's response to harm that can be
elicited by microbes, environmental factors, or internal injuries. This complex physiological …

PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

CA Loynes, JA Lee, AL Robertson, MJG Steel… - Science …, 2018 - science.org
Neutrophils are the first immune cells recruited to a site of injury or infection, where they
perform many functions. Having completed their role, neutrophils must be removed from the …

Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish

A Katikaneni, M Jelcic, GF Gerlach, Y Ma… - Nature cell …, 2020 - nature.com
Rapid wound detection by distant leukocytes is essential for antimicrobial defence and post-
infection survival. The reactive oxygen species hydrogen peroxide and the polyunsaturated …

COVID-19. Pandemic surgery guidance

BLDM Brücher, G Nigri, A Tinelli, J Florencio… - 4 OPEN, 2020 - iris.uniroma1.it
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

Macrophages undergo a behavioural switch during wound healing in zebrafish

T Sipka, SA Park, R Ozbilgic, L Balas, T Durand… - Free Radical Biology …, 2022 - Elsevier
In response to wound signals, macrophages are immediately recruited to the injury where
they acquire distinct phenotypes and functions, playing crucial roles both in host defense …

The fed-batch principle for the molecular biology lab: controlled nutrient diets in ready-made media improve production of recombinant proteins in Escherichia coli

M Krause, A Neubauer, P Neubauer - Microbial Cell Factories, 2016 - Springer
While the nutrient limited fed-batch technology is the standard of the cultivation of
microorganisms and production of heterologous proteins in industry, despite its advantages …

The reaction specificity of mammalian ALOX15 orthologs is changed during late primate evolution and these alterations might offer evolutionary advantages for …

D Heydeck, F Reisch, M Schäfer… - Frontiers in cell and …, 2022 - frontiersin.org
Arachidonic acid lipoxygenases (ALOXs) have been implicated in the immune response of
mammals. The reaction specificity of these enzymes is decisive for their biological functions …

Quantitative shotgun proteomics distinguishes wound-healing biomarker signatures in common carp skin mucus in response to Ichthyophthirius multifiliis

M Saleh, G Kumar, AA Abdel-Baki, MA Dkhil… - Veterinary …, 2018 - Springer
Ichthyophthirius multifiliis is a ciliated protozoan parasite recognized as one of the most
pathogenic diseases of wild and cultured freshwater fish. Fish skin mucus plays a significant …

Structural considerations on lipoxygenase function, inhibition and crosstalk with nitric oxide pathways

I Wood, A Trostchansky, H Rubbo - Biochimie, 2020 - Elsevier
Lipoxygenases (LOX) are non-heme iron-containing enzymes that catalyze regio-and stereo-
selective dioxygenation of polyunsaturated fatty acids (PUFA). Mammalian LOXs participate …