Among sulfur containing heterocycles, benzothiophene and its derivatives are at the focus
as these candidates have structural similarities with active compounds to develop new …

Cornbretastatin A-4 (CA-4) is one of the most potent antinnitotic and antiangiogenic agents
of natural origin. It has displayed potent antitunnor effect in a wide variety of preclinical …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Antimitotic agents have generated considerable interest among cytotoxic agents due to the
tremendous success of the taxanes and the widespread use of the Vinca alkaloids in clinical …

The design of novel anticancer agents based on the combretastatins, a group of antimitotic
agents isolated from the bark of the South African willow tree Combretum caffrum Kuntz, is of …

By synthesis and biological studies of new naphthalene analogues of combretastatins, we
have found that the naphthalene is a good surrogate for the isovanillin moiety (3-hydroxy-4 …

Regioselective hydration of a wide range of internal alkynes has been afforded in high to
good yields by using PTSA in EtOH. The scope of the reaction of alkynes has been …

Highly functional: A copper (I)‐catalyzed intramolecular carbomagnesiation under mild
conditions transforms readily available alkynyl (aryl) thioethers into magnesiated …

A comprehensive review of recent chemistry of α, β-unsaturated sulfoxides and sulfones is
presented. Emphasis has been placed on new reactions and strategies, stereo-and enantio …

The synthesis based on palladium catalytic coupling of 38 new-arylated benzo [b]
thiophenes or thiophenes is described in a few steps. We also report the direct arylation of …