Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films
E Parra, J Pérez-Gil - Chemistry and physics of lipids, 2015 - Elsevier
The respiratory surface in the mammalian lung is stabilized by pulmonary surfactant, a
membrane-based system composed of multiple lipids and specific proteins, the primary …
membrane-based system composed of multiple lipids and specific proteins, the primary …
[HTML][HTML] Structure of pulmonary surfactant membranes and films: the role of proteins and lipid–protein interactions
J Pérez-Gil - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2008 - Elsevier
The pulmonary surfactant system constitutes an excellent example of how dynamic
membrane polymorphism governs some biological functions through specific lipid–lipid …
membrane polymorphism governs some biological functions through specific lipid–lipid …
Pulmonary surfactant pathophysiology: current models and open questions
J Perez-Gil, TE Weaver - Physiology, 2010 - journals.physiology.org
Pulmonary surfactant is an essential lipid-protein complex that stabilizes the respiratory units
(alveoli) involved in gas exchange. Quantitative or qualitative derangements in surfactant …
(alveoli) involved in gas exchange. Quantitative or qualitative derangements in surfactant …
[HTML][HTML] Role of pulmonary surfactant components in surface film formation and dynamics
EJA Veldhuizen, HP Haagsman - Biochimica et biophysica acta (bba) …, 2000 - Elsevier
Pulmonary surfactant is a mixture of lipids and proteins which is secreted by the epithelial
type II cells into the alveolar space. Its main function is to reduce the surface tension at the …
type II cells into the alveolar space. Its main function is to reduce the surface tension at the …
Function of surfactant proteins B and C
TE Weaver, JJ Conkright - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract SP-B is the only surfactant-associated protein absolutely required for postnatal
lung function and survival. Complete deficiency of SP-B in mice and humans results in …
lung function and survival. Complete deficiency of SP-B in mice and humans results in …
Protein–lipid interactions and surface activity in the pulmonary surfactant system
AG Serrano, J Pérez-Gil - Chemistry and physics of lipids, 2006 - Elsevier
Pulmonary surfactant is a lipid–protein complex, synthesized and secreted by the respiratory
epithelium of lungs to the alveolar spaces, whose main function is to reduce the surface …
epithelium of lungs to the alveolar spaces, whose main function is to reduce the surface …
[HTML][HTML] Structure and properties of surfactant protein B
Surfactant protein B is a small homodimeric protein that is found tightly associated with
surfactant lipids in the alveolar space. In this review, we discuss the actions of SP-B on …
surfactant lipids in the alveolar space. In this review, we discuss the actions of SP-B on …
[HTML][HTML] Interfacial properties of surfactant proteins
J Pérez-Gil, KMW Keough - Biochimica et Biophysica Acta (BBA)-Molecular …, 1998 - Elsevier
The main biophysical activity of surfactant is to reduce drastically the surface tension of the
thin aqueous layer lining the respiratory epithelium of lungs (for a recent historical …
thin aqueous layer lining the respiratory epithelium of lungs (for a recent historical …
[HTML][HTML] Structural hallmarks of lung surfactant: Lipid-protein interactions, membrane structure and future challenges
JC Castillo-Sánchez, A Cruz, J Pérez-Gil - Archives of biochemistry and …, 2021 - Elsevier
Lung surfactant (LS) is an outstanding example of how a highly regulated and dynamic
membrane-based system has evolved to sustain a wealth of structural reorganizations in …
membrane-based system has evolved to sustain a wealth of structural reorganizations in …
[HTML][HTML] Physiological fluid interfaces: Functional microenvironments, drug delivery targets, and first line of defense
Fluid interfaces, ie the boundary layer of two liquids or a liquid and a gas, play a vital role in
physiological processes as diverse as visual perception, oral health and taste, lipid …
physiological processes as diverse as visual perception, oral health and taste, lipid …