Insect cell culture for industrial production of recombinant proteins
L Ikonomou, YJ Schneider, SN Agathos - Applied microbiology and …, 2003 - Springer
Insect cells used in conjunction with the baculovirus expression vector system (BEVS) are
gaining ground rapidly as a platform for recombinant protein production. Insect cells present …
gaining ground rapidly as a platform for recombinant protein production. Insect cells present …
Protein production using the baculovirus‐insect cell expression system
A Contreras‐Gómez, A Sánchez‐Mirón… - Biotechnology …, 2014 - Wiley Online Library
The baculovirus‐insect cell expression system is widely used in producing recombinant
proteins. This review is focused on the use of this expression system in developing …
proteins. This review is focused on the use of this expression system in developing …
Antioxidant defense systems of two lipidopteran insect cell lines
Y Wang, LW Oberley, DW Murhammer - Free Radical Biology and …, 2001 - Elsevier
Spodoptera frugiperda Sf-9 (Sf-9) and Trichoplusia ni BTI-Tn-5B1-4 (Tn-5B1-4) insect cell
lines were found to contain unique assemblages of antioxidant enzymes. Specifically, the Sf …
lines were found to contain unique assemblages of antioxidant enzymes. Specifically, the Sf …
Oxygen mass transfer in biopharmaceutical processes: numerical and experimental approaches
Oxygen supply in aerobic bioprocesses is of crucial importance. For this reason, this paper
presents the oxygen demand of different cells and summarizes experimental and numerical …
presents the oxygen demand of different cells and summarizes experimental and numerical …
Insect cells as factories for biomanufacturing
JC Drugmand, YJ Schneider, SN Agathos - Biotechnology advances, 2012 - Elsevier
Insect cells (IC) and particularly lepidopteran cells are an attractive alternative to mammalian
cells for biomanufacturing. Insect cell culture, coupled with the lytic expression capacity of …
cells for biomanufacturing. Insect cell culture, coupled with the lytic expression capacity of …
Evidence of oxidative stress following the viral infection of two lepidopteran insect cell lines
Y Wang, LW Oberley, DW Murhammer - Free Radical Biology and …, 2001 - Elsevier
The infection of Spodoptera frugiperda Sf-9 (Sf-9) and Trichoplusia ni BTI-Tn-5B1-4 (Tn-5B1-
4) insect cell lines with Autographa californica multiple nucleopolyhedrovirus (AcMNPV) …
4) insect cell lines with Autographa californica multiple nucleopolyhedrovirus (AcMNPV) …
Cell density effect in the baculovirus‐insect cells system: A quantitative analysis of energetic metabolism
V Bernal, N Carinhas, AY Yokomizo… - Biotechnology and …, 2009 - Wiley Online Library
The cell density effect (ie, the drop in the specific productivity in the baculovirus‐insect cells
expression system when cells are infected at high cell densities) has been extensively …
expression system when cells are infected at high cell densities) has been extensively …
Insect cells as a production platform of complex virus-like particles
F Fernandes, AP Teixeira, N Carinhas… - Expert review of …, 2013 - Taylor & Francis
Virus-like particles (VLPs) are multiprotein structures that resemble the conformation of
native viruses but lack a viral genome, potentiating their application as safer and cheaper …
native viruses but lack a viral genome, potentiating their application as safer and cheaper …
Stably transformed insect cell lines: tools for expression of secreted and membrane‐anchored proteins and high‐throughput screening platforms for drug and …
Insect cell‐based expression systems are prominent amongst current expression platforms
for their ability to express virtually all types of heterologous recombinant proteins. Stably …
for their ability to express virtually all types of heterologous recombinant proteins. Stably …
[HTML][HTML] Determination of culture design spaces in shaken disposable cultivation systems for CHO suspension cell cultures
RW Maschke, S Seidel, T Bley, R Eibl, D Eibl - Biochemical Engineering …, 2022 - Elsevier
Processes involving mammalian cell cultures-especially CHO suspension cells-dominate
biopharmaceutical manufacturing. These processes are usually developed in small scale …
biopharmaceutical manufacturing. These processes are usually developed in small scale …