[HTML][HTML] CRISPR-Cas9 genome editing approaches in filamentous fungi and oomycetes

M Schuster, R Kahmann - Fungal Genetics and Biology, 2019 - Elsevier
Due to their biotechnological relevance as well as their importance as disease agents,
filamentous fungi and oomycetes have been prime candidates for genetic selection and in …

The interaction of human pathogenic fungi with C-type lectin receptors

S Goyal, JC Castrillón-Betancur, E Klaile… - Frontiers in …, 2018 - frontiersin.org
Fungi, usually present as commensals, are a major cause of opportunistic infections in
immunocompromised patients. Such infections, if not diagnosed or treated properly, can …

Preclinical evaluation of recombinant microbial glycoside hydrolases as antibiofilm agents in acute pulmonary Pseudomonas aeruginosa infection

H Ostapska, D Raju, R Corsini, M Lehoux… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
The bacterium Pseudomonas aeruginosa can colonize the airways of patients with chronic
lung disease. Within the lung, P. aeruginosa forms biofilms that can enhance resistance to …

Hyphae of Rhizopus arrhizus and Lichtheimia corymbifera are more virulent and resistant to antifungal agents than sporangiospores in vitro and in Galleria mellonella

RJR Samdavid Thanapaul, A Roberds, KE Rios… - Journal of Fungi, 2023 - mdpi.com
Mucorales species cause debilitating, life-threatening sinopulmonary diseases in
immunocompromised patients and penetrating wounds in trauma victims. Common …

Industrial production of antibiotics in fungi: current state, deciphering the molecular basis of classical strain improvement and increasing the production of high-yielding …

AA Zhgun - Fermentation, 2023 - mdpi.com
The natural fermentation of antibiotics, along with semi-synthetic and synthetic approaches,
is one of the most important methods for their production. The majority of the antibiotic …

Administration and dosing of systemic antifungal agents in pediatric patients

KJ Downes, BT Fisher, NR Zane - Pediatric Drugs, 2020 - Springer
Neonates and immunosuppressed/immunocompromised pediatric patients are at high risk
of invasive fungal diseases. Appropriate antifungal selection and optimized dosing are …

Filamentous Fungi Infections: Yet Another Victim of COVID-19?

A Cighir, AD Mare, T Cighir, RL Coșeriu, C Vintilă… - Life, 2023 - mdpi.com
Filamentous fungi have always been a matter of concern in the medical field, but nowadays,
due to an increase in the risk factors and the added infections with the SARS-CoV-2 virus …

Development of a TaqMan probe-based multiplex real-time PCR for the simultaneous detection of four clinically important filamentous fungi

Y Wei, Y Lin, J Zhao, D Li, Z Yang, F Chen… - Microbiology …, 2024 - journals.asm.org
Filamentous fungi present significant health hazards to immunocompromised individuals
globally; however, the prompt and precise identification of them during infection remains …

Preclinical evaluation of recombinant microbial glycoside hydrolases in the prevention of experimental invasive aspergillosis

H Ostapska, D Raju, M Lehoux, I Lacdao, S Gilbert… - Mbio, 2021 - Am Soc Microbiol
Aspergillus fumigatus is a ubiquitous mold that can cause invasive pulmonary infections in
immunocompromised patients. Within the lung, A. fumigatus forms biofilms that can enhance …

Electrical signaling beyond neurons

T Monk, N Dennler, N Ralph, S Rastogi, S Afshar… - Neural …, 2024 - direct.mit.edu
Neural action potentials (APs) are difficult to interpret as signal encoders and/or
computational primitives. Their relationships with stimuli and behaviors are obscured by the …