In order to fuel their relentless expansion, cancers must expand their vasculature to augment
delivery of oxygen and essential nutrients. The disordered web of irregular vessels that …

Introduction Cancer is a major global health concern, and immune checkpoint inhibitors
(ICIs) offer a promising treatment option for cancer patients. However, the efficacy of ICIs can …

Introduction Although obesity is associated with adverse cancer outcomes in general, most
retrospective clinical studies suggest a beneficial effect of obesity in NSCLC. Methods …

Metformin has demonstrated antitumor potential in clinical studies; however, achieving
optimal antitumor effects requires administering an extremely safe medication dose. To …

Hyperinsulinemia, hyperglycemia, and chronic inflammation may play a role in
hepatocellular carcinoma (HCC). Treatment of HCC patients with the antidiabetic medication …

Methods| This post hoc secondary analysis used data from a previously published,
prospective, phase 2 randomized clinical trial (RCT). 1 The trial (NCT03071705), along with …

Metformin has been under basic and clinical study as an oncological repurposing
pharmacological agent for several years, stemming from observational studies which …

Cancer is an important threat to public health because of its high morbidity and mortality. In
recent decades, immune checkpoint inhibitors (ICIs) have ushered a new therapeutic era in …

Metformin is a widely used drug in patients with type 2 diabetes mellitus. Metformin inhibits
hepatic gluconeogenesis and increases glucose utilization in peripheral tissues. In recent …

Cancer is a disease caused when cells divide uncontrollably and spread into surrounding
tissues. There are different therapeutic modalities that control cancer growth, of which …