Currently, breast carcinoma is the most common form of malignancy and the main cause of
cancer mortality in women worldwide. The metastasis of cancer cells from the primary tumor …

With 1.67 million new cases and 522,000 deaths in the year 2012, breast cancer is the most
common type of diagnosed malignancy and the second leading cause of cancer death in …

Triple-negative breast cancer (TNBC) represents an aggressive subtype, for which radiation
and chemotherapy are the only options. Here we describe the identification of disulfiram, an …

The present study describes the synthesis of three series of 4-substituted pyridopyrimidin
derivatives 4a-h, 5a-d. 6a-d, starting from 2-amino-6-(4-methoxyphenyl)-4-(4-(substituted) …

Sphingosine-1-phosphate (S1P) is produced by sphingosine kinase 1 and is implicated in
tumor growth, although the mechanisms remain incompletely understood. Pancreatic …

Over the past two decades, huge amounts of research were launched to understand the
functions of sphingosine. Many pathways were uncovered that convey the relative functions …

Breast cancer remains a leading cause of mortality among women worldwide. Brain
metastases confer extremely poor prognosis due to a lack of understanding of their specific …

Summary Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite, which
regulates a broad range of physiological and pathophysiological processes. The signaling …

P-glycoprotein is an ATP-driven xenobiotic export pump that is highly expressed in barrier
and excretory tissues, where it greatly influences drug pharmacokinetics. Recent studies in …

Summary Sphingosine-1-phosphate (S1P) is an important sphingolipid metabolite that
regulates a wide range of physiological and pathophysiological processes. Our previous …