Capsaicin is a potent agonist of the Transient Receptor Potential Vanilloid type 1 (TRPV1)
channel and is a common component found in the fruits of the genus Capsicum plants …

Cardiovascular diseases (CVD) including acute myocardial infarction (AMI) rank first in
worldwide mortality and according to the World Health Organization (WHO), they will stay at …

Patients with diabetes develop endothelial dysfunction shortly after diabetes onset that
progresses to vascular disease underlying the majority of diabetes-associated …

Chronic sympathoexcitation is implicated in ventricular arrhythmogenesis (VAs) following
myocardial infarction (MI), but the critical neural pathways involved are not well understood …

The transient receptor potential (TRP) cation channel superfamily comprises more than 50
channels that play crucial roles in physiological processes. TRP channels are responsive to …

The non-selective cation channel transient receptor potential vanilloid 1 (TRPV1) is
expressed throughout the cardiovascular system. Recent evidence shows a role for TRPV1 …

The Ca2+ release in microdomains formed by intercompartmental contacts, such as
mitochondria-associated endoplasmic reticulum membranes (MAMs), encodes a signal that …

Mitochondria are essential intracellular organelles that regulate energy metabolism, cell
death, and signaling pathways that are important for cell proliferation and differentiation …

Background Type 2 diabetes mellitus (T2DM) is a major 21st-century epidemic. T2DM
elevates the risk of myocardial infarction and heart failure while also reducinges survival …

TRPV1 acts as a unique polymodal ion channel having distinct structure and gating
properties. In this context, TRPV1-R575D represents a special mutant located at the inner …