The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and
schizophrenia, affect a significant percentage of the world population. These disorders are …
schizophrenia, affect a significant percentage of the world population. These disorders are …
[HTML][HTML] Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
EH Douma, ER de Kloet - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …
motivational, and social reward associations together with their more demanding cognitive …
Associations of depression, anxiety, worry, perceived stress, and loneliness prior to infection with risk of post–COVID-19 conditions
Importance Few risk factors for long-lasting (≥ 4 weeks) COVID-19 symptoms have been
identified. Objective To determine whether high levels of psychological distress before …
identified. Objective To determine whether high levels of psychological distress before …
Gut microbiota, bacterial translocation, and interactions with diet: pathophysiological links between major depressive disorder and non-communicable medical …
Background: Persistent low-grade immune-inflammatory processes, oxidative and
nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to …
nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to …
Targeting the adaptive immune system in depression: focus on T helper 17 cells
There is a vital need to understand mechanisms contributing to susceptibility to depression
to improve treatments for the 11% of Americans who currently suffer from this debilitating …
to improve treatments for the 11% of Americans who currently suffer from this debilitating …
The influence of antidepressants on the immune system
ŁP Szałach, KA Lisowska, WJ Cubała - Archivum immunologiae et …, 2019 - Springer
Depression is one of the most frequently diagnosed condition in psychiatry. Despite the
availability of many preparations, over 30% of treated patients do not achieve remission …
availability of many preparations, over 30% of treated patients do not achieve remission …
Early-life social isolation-induced depressive-like behavior in rats results in microglial activation and neuronal histone methylation that are mitigated by minocycline
HT Wang, FL Huang, ZL Hu, WJ Zhang, XQ Qiao… - Neurotoxicity …, 2017 - Springer
Early-life stress is a potent risk factor for development of psychiatric conditions such as
depression. The underlying mechanisms remain poorly understood. Here, we used the early …
depression. The underlying mechanisms remain poorly understood. Here, we used the early …
The microbiota-gut-immune-glia (MGIG) axis in major depression
There is robust evidence that major depression (MDD) is accompanied by a low-grade
activation of the immune-inflammatory response system, which is involved in the …
activation of the immune-inflammatory response system, which is involved in the …
Cognitive dysfunction in depression–pathophysiology and novel targets
AF Carvalho, KK Miskowiak… - CNS & Neurological …, 2014 - ingentaconnect.com
Major depressive disorder (MDD) is associated with cognitive dysfunction encompassing
several domains, including memory, executive function, processing speed and attention …
several domains, including memory, executive function, processing speed and attention …
T helper 17 cells may drive neuroprogression in major depressive disorder: proposal of an integrative model
The exact pathophysiology of major depressive disorder (MDD) remains elusive. The
monoamine theory, which hypothesizes that MDD emerges as a result of dysfunctional …
monoamine theory, which hypothesizes that MDD emerges as a result of dysfunctional …