Animal experimentation helps us to understand human biology. Rodents and, in particular,
rats are among the most common animals used in animal experiments. Reporting data on …

In recent years dietary interventions have become a promising tool in cancer treatment and
have demonstrated a powerful ability to alter metabolism and tumor growth, development …

Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported
as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is …

В монографии проанализированы основные концепции о природе старения, история
их возникновения и эволюция. Изложены современные представления о …

The main objective of this review is to provide an appraisal of the current status of the
relationship between energy intake and the life span of animals. The concept that a …

The glyoxalase system has been studied since 1913. The biochemical function of this
enzymatic system is the metabolism of reactive dicarbonyl metabolites, glyoxal and …

This report reviews decade two of the lifetime diet restriction study of the dog. Labrador
retrievers (n 48) were paired at age 6 weeks by sex and weight within each of seven litters …

BACKGROUND: Visceral fat (VF) accretion is a hallmark of aging in humans. Epidemiologic
studies have implicated abdominal obesity as a major risk factor for insulin resistance, type 2 …

The prevalence of obesity, an established epidemiological risk factor for many cancers, has
risen steadily for the past several decades in the US and many other countries. Particularly …

Previous studies have shown that caloric restriction decreases mitochondrial oxygen radical
production and oxidative DNA damage in rat organs, which can be linked to the slowing of …