Rationale: Noninvasive ventilation (NIV) is increasingly used in patients with acute
respiratory distress syndrome (ARDS). The evidence supporting NIV use in patients with …

In acute hypoxemic respiratory failure (AHRF) and acute respiratory distress syndrome
(ARDS) patients, spontaneous breathing is associated with multiple physiologic benefits: it …

Abstract Background The Japanese Society of Respiratory Care Medicine and the Japanese
Society of Intensive Care Medicine provide here a clinical practice guideline for the …

Rationale: Spontaneous breathing during mechanical ventilation increases transpulmonary
pressure and Vt, and worsens lung injury. Intuitively, controlling Vt and transpulmonary …

Objectives: Lung-protective ventilation for acute respiratory distress syndrome aims for
providing sufficient oxygenation and carbon dioxide clearance, while limiting the harmful …

Background Acute hypoxemic respiratory failure (AHRF) is a major factor for increased
mortality in the intensive care unit (ICU). We hypothesized that the noninvasive index SpO …

Background Mechanical ventilation is an essential therapy to support critically ill respiratory
failure patients. Current standards of care consist of generalised approaches, such as the …

Targeting inflammasome activation to modulate interleukin (IL)-1β is a promising treatment
strategy against acute respiratory distress syndrome and ventilator-induced lung injury …

Objectives Major observational studies report that the mortality rate of acute respiratory
distress syndrome (ARDS) is close to 40%. Different treatment strategies are required for …

The acute respiratory distress syndrome (ARDS) is a complication of critical illness that is
characterized by acute onset, protein rich, pulmonary edema. There is no treatment for …