R-loops are non-B DNA structures with intriguing dual consequences for gene expression
and genome stability. In addition to their recognized roles in triggering DNA double-strand …

DNA damage poses a serious threat to human health and cells therefore continuously
monitor and repair DNA lesions across the genome. Ribosomal DNA is a genomic domain …

RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA
damage response (DDR). The RBP FUS is implicated in RNA metabolism and DNA repair …

Subcellular compartmentalization contributes to the organization of a plethora of molecular
events occurring within cells. This can be achieved in membraneless organelles generated …

The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism.
Here we show that the exosome is necessary for the repair of DNA double-strand breaks …

Although long overlooked, it is now well understood that DNA does not systematically
assemble into a canonical double helix, known as B-DNA, throughout the entire genome but …

All organisms must safeguard the integrity of their DNA to avoid deleterious consequences
of genome instability, which have been linked to human diseases such as autoimmune …

The recent discovery of DNA: RNA hybrids, or R-loops, actively forming at DNA double-
strand breaks (DSBs) has unlocked fresh insight into how RNA participates in DNA repair …

DNA is constantly exposed to endogenous and exogenous damage. Various types of DNA
repair counteract highly toxic DNA double-strand breaks (DSBs) to maintain genome …

Formation of biomolecular condensates is increasingly recognized as a mechanism
employed by cells to deal with stress and to optimize enzymatic reactions. Recent studies …