Resistance to tyrosine kinase inhibitors in chronic myeloid leukemia—from molecular mechanisms to clinical relevance
Simple Summary Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia
associated with a molecular alteration, the fusion gene BCR-ABL1, that encodes the tyrosine …
associated with a molecular alteration, the fusion gene BCR-ABL1, that encodes the tyrosine …
Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets
F Shu, H Xiao, QN Li, XS Ren, ZG Liu, BW Hu… - … and Targeted Therapy, 2023 - nature.com
Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …
dynamically degraded and re-processed to maintain physical homeostasis. However, the …
Targeting autophagy during cancer therapy to improve clinical outcomes
JMM Levy, A Thorburn - Pharmacology & therapeutics, 2011 - Elsevier
Autophagy is a catabolic process that turns over long-lived proteins and organelles and
contributes to cell and organism survival in times of stress. Current cancer therapies …
contributes to cell and organism survival in times of stress. Current cancer therapies …
Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia
J Jelinek, V Gharibyan, MRH Estecio, K Kondo, R He… - PloS one, 2011 - journals.plos.org
The epigenetic impact of DNA methylation in chronic myelogenous leukemia (CML) is not
completely understood. To elucidate its role we analyzed 120 patients with CML for …
completely understood. To elucidate its role we analyzed 120 patients with CML for …
Gene-set analysis is severely biased when applied to genome-wide methylation data
Motivation: DNA methylation is an epigenetic mark that can stably repress gene expression.
Because of its biological and clinical significance, several methods have been developed to …
Because of its biological and clinical significance, several methods have been developed to …
Concise review: chronic myeloid leukemia: stem cell niche and response to pharmacologic treatment
E Arrigoni, M Del Re, S Galimberti… - Stem cells …, 2018 - academic.oup.com
Nowadays, more than 90% of patients affected by chronic myeloid leukemia (CML) survive
with a good quality of life, thanks to the clinical efficacy of tyrosine kinase inhibitors (TKIs) …
with a good quality of life, thanks to the clinical efficacy of tyrosine kinase inhibitors (TKIs) …
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
S Kalari, GP Pfeifer - Advances in genetics, 2010 - Elsevier
Human cancer genomes are characterized by widespread aberrations in DNA methylation
patterns including DNA hypomethylation of mostly repetitive sequences and …
patterns including DNA hypomethylation of mostly repetitive sequences and …
Epigenomics of leukemia: from mechanisms to therapeutic applications
C Florean, M Schnekenburger, C Grandjenette… - …, 2011 - Future Medicine
Leukemogenesis is a multistep process in which successive transformational events
enhance the ability of a clonal population arising from hematopoietic progenitor cells to …
enhance the ability of a clonal population arising from hematopoietic progenitor cells to …
CpG island methylation profiling in human salivary gland adenoid cystic carcinoma
A Bell, D Bell, RS Weber, AK El‐Naggar - Cancer, 2011 - Wiley Online Library
BACKGROUND: DNA methylation is a fundamental epigenetic event associated with
physiologic and pathologic conditions, including cancer. Hypermethylation of CpG islands at …
physiologic and pathologic conditions, including cancer. Hypermethylation of CpG islands at …
Advances in genome-wide DNA methylation analysis
R Gupta, A Nagarajan, N Wajapeyee - Biotechniques, 2010 - Future Science
The covalent DNA modification of cytosine at position 5 (5-methylcytosine; 5mC) has
emerged as an important epigenetic mark most commonly present in the context of CpG …
emerged as an important epigenetic mark most commonly present in the context of CpG …