Adolescent idiopathic scoliosis

JC Cheng, RM Castelein, WC Chu… - Nature reviews disease …, 2015 - nature.com
Adolescent idiopathic scoliosis (AIS) is the most common form of structural spinal deformities
that have a radiological lateral Cobb angle—a measure of spinal curvature—of≥ 10. AIS …

Adolescent idiopathic scoliosis: a review of aetiological theories of a multifactorial disease

S Marya, AD Tambe, PA Millner… - The bone & joint …, 2022 - boneandjoint.org.uk
Adolescent idiopathic scoliosis (AIS), defined by an age at presentation of 11 to 18 years,
has a prevalence of 0.47% and accounts for approximately 90% of all cases of idiopathic …

Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis

I Kou, Y Takahashi, TA Johnson, A Takahashi, L Guo… - Nature …, 2013 - nature.com
Adolescent idiopathic scoliosis (AIS) is the most common pediatric skeletal disease. We
previously reported a locus on chromosome 10q24. 31 associated with AIS susceptibility in …

[HTML][HTML] Incidence and surgery rate of idiopathic scoliosis: a nationwide database study

S Sung, HW Chae, HS Lee, S Kim, JW Kwon… - International journal of …, 2021 - mdpi.com
Idiopathic scoliosis is the most common cause of three-dimensional deformities of the spine.
Most of the previous studies have been cross-sectional studies to estimate the prevalence in …

A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis

Y Takahashi, I Kou, A Takahashi, TA Johnson, K Kono… - Nature …, 2011 - nature.com
Adolescent idiopathic scoliosis is a pediatric spinal deformity affecting 2–3% of school-age
children worldwide. Genetic factors have been implicated in its etiology. Through a genome …

Top theories for the etiopathogenesis of adolescent idiopathic scoliosis

WJ Wang, HY Yeung, WCW Chu… - Journal of Pediatric …, 2011 - journals.lww.com
Background Despite considerable advances in the past few decades, there is no generally
accepted “top theory or theories” of the etiology of adolescent idiopathic scoliosis (AIS). This …

From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis

G Pérez-Machado, E Berenguer-Pascual… - Bone, 2020 - Elsevier
Scoliosis is defined as the three-dimensional (3D) structural deformity of the spine with a
radiological lateral Cobb angle (a measure of spinal curvature) of≥ 10° that can be caused …

[HTML][HTML] Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls

Z Zhu, NLS Tang, L Xu, X Qin, S Mao, Y Song… - Nature …, 2015 - nature.com
Adolescent idiopathic scoliosis (AIS) is a structural deformity of the spine affecting millions of
children. As a complex disease, the genetic aetiology of AIS remains obscure. Here we …

[HTML][HTML] Pathogenesis of adolescent idiopathic scoliosis in girls-a double neuro-osseous theory involving disharmony between two nervous systems, somatic and …

RG Burwell, RK Aujla, MP Grevitt, PH Dangerfield… - Scoliosis, 2009 - Springer
Anthropometric data from three groups of adolescent girls-preoperative adolescent
idiopathic scoliosis (AIS), screened for scoliosis and normals were analysed by comparing …

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis

JG Buchan, DM Alvarado, GE Haller… - Human molecular …, 2014 - academic.oup.com
Adolescent idiopathic scoliosis (AIS) causes spinal deformity in 3% of children. Despite a
strong genetic basis, few genes have been associated with AIS and the pathogenesis …