In this review, we have focused mainly on the study of their antioxidant and pro-oxidant
capacity, and the analysis of the oxidation of the catechol group to o-quinone. The redox …

Quinones are ubiquitous in nature and constitute an important class of naturally occurring
compounds found in plants, fungi and bacteria. Human exposure to quinones therefore …

Quinones represent a class of toxicological intermediates, which can create a variety of
hazardous effects in vivo including, acute cytotoxicity, immunotoxicity, and carcinogenesis …

This is an overview of the metabolic activation of drugs, natural products, physiological
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …

Paroxetine, a selective serotonin reuptake inhibitor, is a potent inhibitor of cytochrome P450
2D6 (CYP2D6) activity, but the mechanism of inhibition is not established. To determine …

The present review focuses on the mechanisms of mutagenic action and the carcinogenic
risk of two categories of botanical ingredients, namely the flavonoids with quercetin as an …

Alkenylbenzenes represent a group of naturally occurring substances that are synthesized
as secondary metabolites in various plants, including nutmeg and basil. Many of the …

Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human
liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide …

Cytochrome P450 constitute a superfamily of heme-containing enzymes that catalyze the
oxidative biotransformation of structurally diverse xenobiotics including drugs. Inhibition of …

GSH was readily depleted by a flavonoid, H2O2, and peroxidase mixture but the products
formed were dependent on the redox potential of the flavonoid. Catalytic amounts of …