Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …

How do individual cells organize into multicellular tissues? Here, we propose that the
morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic …

Hypoxia unleashes the invasive and metastatic potential of tumor cells by largely unknown
mechanisms. The Met tyrosine kinase, a high affinity receptor for hepatocyte growth factor …

Mature podocytes are among the most complex differentiated cells and possess a highly
branched array of foot processes that are essential to glomerular filtration in the kidney …

A number of developmental processes that involve cell migration, growth or morphogenesis
depend on extracellular signals. A molecule that provides such signals, known as …

In this review, we define the two major tissue types, epithelium and mesenchyme, and we
describe the transformations (transdifferentiations) of epithelium to mesenchyme (EMT) and …

The Met receptor tyrosine kinase is the prototypic member of a small subfamily of growth
factor receptors that when activated induce mitogenic, motogenic, and morphogenic cellular …

Every year about 500,000 people in the United States die as a result of cancer. Among them,
90% exhibit systemic disease with metastasis. Considering this high rate of incidence and …

Pediatric Nephrology is the premier comprehensive reference on congenital and acquired
kidney diseases and their therapies in children. Section One opens with an overview of the …

Specific tissue interactions between epithelia and mesenchyme (or stroma), eg, epithelial-
mesenchymal (or-stromal) interactions mediate crucial aspects of normal development and …