Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …

Simple Summary Gastric cancer (GC) is one of the most common cancers and the third
leading cause of cancer deaths worldwide, with a high frequency of recurrence and …

Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver
as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic …

The establishment and maintenance of epithelial cell-cell junctions is crucially important to
regulate adhesion, apico-basal polarity and motility of epithelial cells, and ultimately controls …

The breakdown of the intestinal barrier is a common manifestation of many diseases. Recent
evidence suggests that vitamin D and its receptor VDR may regulate intestinal barrier …

Tight junction (TJ) proteins form a continuous intercellular network creating a barrier with
selective regulation of water, ion, and solutes across endothelial, epithelial, and glial tissues …

Abstract The role of 27-hydroxycholesterol (27-OHC) in autoimmune diseases has become
a subject of intense research in recent years. This oxysterol, derived from cholesterol, has …

Tight junction (TJ) is the barrier of epithelial and endothelial cells to maintain paracellular
substrate transport and cell polarity. As one of the TJ cytoplasmic adaptor proteins adjacent …

Tight junctions are essential for barrier integrity, inflammation, and cancer. Vitamin D and the
vitamin D receptor (VDR) play important roles in colorectal cancer (CRC). Using the human …

The formation, maintenance, and repair of epithelial barriers are of critical importance for
whole-body homeostasis. However, the molecular events involved in epithelial tissue …