Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

Genetic studies in animals and humans indicate that gene mutations that functionally perturb
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …

Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the
presence of pathology (eg, cancer), and it is these types of environments in which …

Angiogenesis is defined as a new blood vessel sprouting from pre-existing vessels. This
highly regulated process take place through two non-exclusive events, the so-called …

Fluid shear forces have established roles in blood vascular development and function, but
whether such forces similarly influence the low-flow lymphatic system is unknown. It has …

Schlemm's canal (SC) plays central roles in ocular physiology. These roles depend on the
molecular phenotypes of SC endothelial cells (SECs). Both the specific phenotype of SECs …

The lineage and developmental trajectory of a cell are key determinants of cellular identity.
In the vascular system, endothelial cells (ECs) of blood and lymphatic vessels differentiate …

Schlemm's canal (SC) is a specialized vascular structure in the eye that functions to drain
aqueous humor from the intraocular chamber into systemic circulation. Dysfunction of SC …

The mammalian lymphatic vasculature is important for returning fluids from the extracellular
tissue milieu back to the blood circulation. We showed previously that Prox1 dosage is …

Solid tumor pathophysiology is characterized by an abnormal microenvironment that guides
tumor progression and poses barriers to the efficacy of cancer therapies. Most common …