Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration.
Many neurodegenerative diseases are age-related, including two of the most common …

Background Parkinson's disease is a neurological disorder with complex pathogenesis
implicating both environmental and genetic factors. We aimed to summarise the …

Efforts to develop neuroprotective therapy for Parkinson disease (PD) are focusing on the
early stages of disease, which offer the best opportunity to intervene. Early PD can be …

Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor
symptoms. Relationship between premotor symptoms onset and motor features is limited …

Objectives: Determine diagnostic accuracy of a clinical diagnosis of Parkinson disease (PD)
using neuropathologic diagnosis as the gold standard. Methods: Data from the Arizona …

The past decade has seen a dramatic expansion of the field of prodromal PD. Ten years
ago, there were only six known prodromal markers of disease, none of which had more than …

Parkinson's disease (PD) is currently clinically defined by a set of cardinal motor features
centred on the presence of bradykinesia and at least one additional motor symptom out of …

Significant progress has been made in understanding the pre-symptomatic phase of
amyotrophic lateral sclerosis. While much is still unknown, advances in other …

The ultimate goal in Parkinson's disease (PD) research remains the identification of
treatments that are capable of slowing or even halting the progression of the disease. The …

Background: Poor olfaction is common among older adults and has been linked to higher
mortality. However, most studies have had a relatively short follow-up and have not explored …