Despite continuous improvements in delivery systems, the development of methods for
efficient and specific delivery of targeted therapeutic agents still remains an issue in …

Taking a strand: Aptamers are small singlestranded oligonucleotides that fold into a well
defined 3D structure and interact with high affinity and specificity with their target molecules …

RNA interference constitutes a powerful tool for biological studies, but has also become one
of the most challenging therapeutic strategies. However, small interfering RNA (siRNA) …

The main benefit of natural peptides, peptide analogs and newly designed peptides as
therapeutics, lies in their high selectivity and affinity, which are frequently in the nanomolar …

Cell-penetrating peptide based vehicles have been developed for the delivery of different
payloads into the cells in culture and in animals. However, several biological features …

During the three decades of cell-penetrating peptides era the superfamily of CPPs has
rapidly expanded, and the quest for new sequences continues. CPPs have been well …

Major indications for use of peptide-based therapeutics include endocrine functions
(especially diabetes mellitus and obesity), infectious diseases, and cancer. Whereas some …

We developed multifunctional fluorescent nanoparticles suitable for the nonviral delivery of
negatively charged molecules like RNA. Therefore, we incorporated the recently developed …

The recent discovery of new potent therapeutic molecules that do not reach the clinic due to
poor delivery and low bioavailability has made of delivery a keystone in therapeutic …

Despite the fact that non-viral nucleic acid delivery systems are generally considered to be
less efficient than viral vectors, they have gained much interest in recent years due to their …