Small cell lung cancer (SCLC) is a rapidly growing, highly metastatic, and relatively immune-
cold lung cancer subtype. Historically viewed in the laboratory and clinic as a single …

The Hippo pathway plays a critical role for balancing proliferation and differentiation, thus
regulating tissue homeostasis. The pathway acts through a kinase cascade whose final …

Simple Summary The tyrosine kinase receptor Axl is an oncogene that promotes cancer
development by increasing proliferation, survival, invasion, and migration in cancer cells. Axl …

Simple Summary YAP and TAZ are transcriptional cofactors that integrate several upstream
signals to generate context-dependent transcriptional responses. This requires extensive …

Background The high mutation rate throughout the entire melanoma genome presents a
major challenge in stratifying true driver events from the background mutations. Numerous …

Objective We aimed to understand the role of the transcriptional co-factor Yes-associated
protein (Yap) in the molecular pathway underpinning the pathogenic transformation of …

Melanoma is the deadliest form of skin cancer. Although targeted therapies and
immunotherapies have revolutionized the treatment of metastatic melanoma, most patients …

The nongenetic mechanisms required to control tumor phenotypic plasticity and shape drug‐
resistance remain unclear. We show here that the Aryl hydrocarbon Receptor (AhR) …

Skin cancers are by far the most frequently diagnosed human cancers. The closely related
transcriptional co‐regulator proteins YAP and TAZ (WWTR1) have emerged as important …

Oncogene-induced senescence (OIS) is an important process that suppresses tumor
development, but the molecular mechanisms of OIS are still under investigation. It is known …