[HTML][HTML] Plasticity of innate lymphoid cell subsets

SM Bal, K Golebski, H Spits - Nature Reviews Immunology, 2020 - nature.com
Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can …

How do uterine natural killer and innate lymphoid cells contribute to successful pregnancy?

O Huhn, X Zhao, L Esposito, A Moffett… - Frontiers in …, 2021 - frontiersin.org
Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both
before and during pregnancy. Circumstantial evidence suggests they play important roles in …

Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation

AP McFarland, A Yalin, SY Wang, VS Cortez… - Immunity, 2021 - cell.com
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate
lymphocytes broadly defined in mice as Lin− NK1. 1+ NKp46+ cells that express the …

[HTML][HTML] In situ maturation and tissue adaptation of type 2 innate lymphoid cell progenitors

P Zeis, M Lian, X Fan, JS Herman, DC Hernandez… - Immunity, 2020 - cell.com
Innate lymphoid cells (ILCs) are generated early during ontogeny and persist predominantly
as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within …

[HTML][HTML] Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues

C Friedrich, RLRE Taggenbrock… - Nature …, 2021 - nature.com
Innate lymphoid cells (ILCs) participate in tissue homeostasis, inflammation, and early
immunity against infection. It is unclear how ILCs acquire effector function and whether these …

Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity

I Dean, CYC Lee, ZK Tuong, Z Li, CA Tibbitt… - Nature …, 2024 - nature.com
Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of
cancer progression. Established tumors contain phenotypically distinct, tumor-specific …

[HTML][HTML] Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity

R Fiancette, CM Finlay, C Willis, SL Bevington… - Nature …, 2021 - nature.com
Innate lymphoid cells (ILCs) are guardians of mucosal immunity, yet the transcriptional
networks that support their function remain poorly understood. We used inducible …

Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis

M Zhao, F Shao, D Yu, J Zhang, Z Liu, J Ma… - Nature …, 2022 - nature.com
Innate lymphoid cells (ILC) are abundant in mucosal tissues. They serve critical functions in
anti-pathogen response and tissue homeostasis. However, the heterogenous composition of …

[HTML][HTML] RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus

ACF Ferreira, ACH Szeto, MWD Heycock, PA Clark… - Nature …, 2021 - nature.com
Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity
and tissue repair. Here we demonstrate that functional ILC2 cells can arise in the embryonic …

[HTML][HTML] Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets

M Ghaedi, ZY Shen, M Orangi… - Journal of Experimental …, 2020 - rupress.org
Lung group 2 innate lymphoid cells (ILC2s) drive allergic inflammation and promote tissue
repair. ILC2 development is dependent on the transcription factor retinoic acid receptor …