[HTML][HTML] Plasticity of innate lymphoid cell subsets
Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can …
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can …
How do uterine natural killer and innate lymphoid cells contribute to successful pregnancy?
Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both
before and during pregnancy. Circumstantial evidence suggests they play important roles in …
before and during pregnancy. Circumstantial evidence suggests they play important roles in …
Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate
lymphocytes broadly defined in mice as Lin− NK1. 1+ NKp46+ cells that express the …
lymphocytes broadly defined in mice as Lin− NK1. 1+ NKp46+ cells that express the …
[HTML][HTML] In situ maturation and tissue adaptation of type 2 innate lymphoid cell progenitors
Innate lymphoid cells (ILCs) are generated early during ontogeny and persist predominantly
as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within …
as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within …
[HTML][HTML] Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues
C Friedrich, RLRE Taggenbrock… - Nature …, 2021 - nature.com
Innate lymphoid cells (ILCs) participate in tissue homeostasis, inflammation, and early
immunity against infection. It is unclear how ILCs acquire effector function and whether these …
immunity against infection. It is unclear how ILCs acquire effector function and whether these …
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of
cancer progression. Established tumors contain phenotypically distinct, tumor-specific …
cancer progression. Established tumors contain phenotypically distinct, tumor-specific …
[HTML][HTML] Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity
R Fiancette, CM Finlay, C Willis, SL Bevington… - Nature …, 2021 - nature.com
Innate lymphoid cells (ILCs) are guardians of mucosal immunity, yet the transcriptional
networks that support their function remain poorly understood. We used inducible …
networks that support their function remain poorly understood. We used inducible …
Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis
M Zhao, F Shao, D Yu, J Zhang, Z Liu, J Ma… - Nature …, 2022 - nature.com
Innate lymphoid cells (ILC) are abundant in mucosal tissues. They serve critical functions in
anti-pathogen response and tissue homeostasis. However, the heterogenous composition of …
anti-pathogen response and tissue homeostasis. However, the heterogenous composition of …
[HTML][HTML] RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
ACF Ferreira, ACH Szeto, MWD Heycock, PA Clark… - Nature …, 2021 - nature.com
Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity
and tissue repair. Here we demonstrate that functional ILC2 cells can arise in the embryonic …
and tissue repair. Here we demonstrate that functional ILC2 cells can arise in the embryonic …
[HTML][HTML] Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets
M Ghaedi, ZY Shen, M Orangi… - Journal of Experimental …, 2020 - rupress.org
Lung group 2 innate lymphoid cells (ILC2s) drive allergic inflammation and promote tissue
repair. ILC2 development is dependent on the transcription factor retinoic acid receptor …
repair. ILC2 development is dependent on the transcription factor retinoic acid receptor …