Ceria‐based therapeutic antioxidants for biomedical applications

YG Kim, Y Lee, N Lee, M Soh, D Kim… - Advanced …, 2024 - Wiley Online Library
The growing interest in nanomedicine over the last 20 years has carved out a research field
called “nanocatalytic therapy,” where catalytic reactions mediated by nanomaterials are …

[HTML][HTML] Natural products: potential treatments for cisplatin-induced nephrotoxicity

C Fang, D Lou, L Zhou, J Wang, B Yang, Q He… - Acta Pharmacologica …, 2021 - nature.com
Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment
of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer …

[HTML][HTML] Acute kidney injury: definition, pathophysiology and clinical phenotypes

K Makris, L Spanou - The clinical biochemist reviews, 2016 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is a clinical syndrome that complicates the course and worsens the
outcome in a significant number of hospitalised patients. Recent advances in clinical and …

[HTML][HTML] Acute kidney injury

A Zuk, JV Bonventre - Annual review of medicine, 2016 - annualreviews.org
Acute kidney injury (AKI) is a global public health concern associated with high morbidity,
mortality, and healthcare costs. Other than dialysis, no therapeutic interventions reliably …

[HTML][HTML] Mechanisms and therapeutic targets of ischemic acute kidney injury

SJ Han, HT Lee - Kidney research and clinical practice, 2019 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem
without effective therapy and is a significant and frequent cause of morbidity and mortality …

Failed tubule recovery, AKI-CKD transition, and kidney disease progression

MA Venkatachalam, JM Weinberg, W Kriz… - Journal of the …, 2015 - journals.lww.com
The transition of AKI to CKD has major clinical significance. As reviewed here, recent studies
show that a subpopulation of dedifferentiated, proliferating tubules recovering from AKI …

ROS‐mediated NLRP3 inflammasome activation in brain, heart, kidney, and testis ischemia/reperfusion injury

L Minutoli, D Puzzolo, M Rinaldi, N Irrera… - Oxidative medicine …, 2016 - Wiley Online Library
Ischemia and reperfusion (I/R) causes a reduction in arterial blood supply to tissues,
followed by the restoration of perfusion and consequent reoxygenation. The reestablishment …

Pathophysiology of cisplatin‐induced acute kidney injury

A Ozkok, CL Edelstein - BioMed research international, 2014 - Wiley Online Library
Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents
to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A …

Defining physiological normoxia for improved translation of cell physiology to animal models and humans

TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

[HTML][HTML] Pathophysiology of acute kidney injury

DP Basile, MD Anderson, TA Sutton - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …