Is metformin neuroprotective against diabetes mellitus-induced neurodegeneration? An updated graphical review of molecular basis

F Karami, H Jamaati, N Coleman-Fuller, MS Zeini… - Pharmacological …, 2023 - Springer
Diabetes mellitus (DM) is a metabolic disease that activates several molecular pathways
involved in neurodegenerative disorders. Metformin, an anti-hyperglycemic drug used for …

Design and Synthesis of Pyrazole‐3‐one Derivatives as Hypoglycaemic Agents

PA Datar, SR Jadhav - International Journal of Medicinal …, 2015 - Wiley Online Library
Pyrazole‐3‐one compounds were designed on the basis of docking studies of previously
reported antidiabetic pyrazole compounds. The amino acid residues found during docking …

Sweet old memories: a review of the experimental models of the association between diabetes, senility and dementia

OB Akinola - Metabolic Brain Disease, 2016 - Springer
Abstract7 As the burden of Alzheimer's dementia rises, so does our understanding of the
cellular and molecular basis of this neurodegenerative disease. Some of the recent …

Metformin-induced protection against oxidative stress is associated with AKT/mTOR restoration in PC12 cells

B Khallaghi, F Safarian, S Nasoohi, A Ahmadiani… - Life sciences, 2016 - Elsevier
Aims Reactive oxygen species have been recognized to impair cell function through
suppressing Akt the well-known pro-survival molecule. Pile of concrete evidence imply …

Synthesis, docking and antidiabetic activity of some newer benzamide derivatives as potential glucokinase activators

R Singh, V Lather, D Pandita, V Judge… - Letters in Drug …, 2017 - benthamdirect.com
Background: Glucokinase activators (GKAs) are the new class of candidate drugs which act
on glucokinase (GK) enzyme and show their hypoglycaemic activity. Objective: The present …

Prevention and treatment of brain damage in streptozotocin induced diabetic rats with Metformin, Nigella sativa, Zingiber officinale, and Punica granatum

SMA Sangi, NA Al Jalaud - Biomedical Research and Therapy, 2019 - bmrat.com
Introduction: Diabetes mellitus (DM) is well-known metabolic disorder, which causes serious
effects on human health with its complications. Many mechanisms has been postulated to …

Internet of Things (Iot): It's application for sustainable agricultural productivity in Nigeria

FO Bamigboye, EO Ademola - 2016 - eprints.abuad.edu.ng
The paper considered Internet of things as it applies to agriculture. It's relevance in the area
of weather forecast, irrigation/fertilizer application, tracking of farm produce, internet banking …

[HTML][HTML] Potential Antidiabetic Activities of Probiotic Strains, L. acidophilus and L. bulgaricus against Fructose-Fed Hyperglycemic Rats

MSU Sohag, M Paul, MAA Al-Bari, MII Wahed… - Food and Nutrition …, 2019 - scirp.org
Background: Deregulation of the gut microbiota results in various pathological disorders
such as diabetes, inflammation, cancer, dyslipidemia etc. Modulation of intestinal microbiota …

Evaluation of conventional therapeutic methods versus maggot therapy in the evolution of healing of tegumental injuries in Wistar rats with and without diabetes …

FS Masiero, PJ Thyssen - Parasitology research, 2016 - Springer
Larval therapy consists on the application of sterilized carrion flies larvae, reared in
laboratory, on acute, chronic, and/or infected wounds in order to promote healing …

Amelioration of thyroid dysfunction by magnesium in experimental diabetes may also prevent diabetes-induced renal impairment

AO Ige, RN Chidi, EE Egbeluya, RO Jubreel, BO Adele… - Heliyon, 2019 - cell.com
Background Diabetes mellitus has been reported to cause thyroid dysfunction, which may
also impair renal function. Magnesium has been reported to exert ameliorative effects in …